S
Shivan Chetty
Researcher at University of Cape Town
Publications - 17
Citations - 320
Shivan Chetty is an academic researcher from University of Cape Town. The author has contributed to research in topics: Fusion protein & Mycobacterium tuberculosis. The author has an hindex of 9, co-authored 16 publications receiving 238 citations. Previous affiliations of Shivan Chetty include Duke University & University of KwaZulu-Natal.
Papers
More filters
Journal ArticleDOI
Prospective Monitoring Reveals Dynamic Levels of T Cell Immunity to Mycobacterium Tuberculosis in HIV Infected Individuals
Jessica E. Mitchell,Shivan Chetty,Pamla Govender,Mona Pillay,Manjeetha Jaggernath,Anne Kasmar,Thumbi Ndung'u,Thumbi Ndung'u,Paul Klenerman,Bruce D. Walker,Bruce D. Walker,Victoria O. Kasprowicz,Victoria O. Kasprowicz +12 more
TL;DR: The RD1-Elispot appears to have limited value in this setting and was performed every 3 months for a period of 3–21 months.
Journal ArticleDOI
Targeted human cytolytic fusion proteins at the cutting edge: harnessing the apoptosis-inducing properties of human enzymes for the selective elimination of tumor cells.
TL;DR: Preclinically tested human cytolytic fusion proteins (hCFPs) have proven promising as non-immunogenic combinatory anti-cancer agents, however they still require further enhancement to achieve convincing candidacy as a single-mode therapeutic.
Journal ArticleDOI
Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation
Anna Bochicchio,Anna Bochicchio,Sandra Jordaan,Valeria Losasso,Shivan Chetty,Rodrigo Casasnovas Perera,Emiliano Ippoliti,Stefan Barth,Paolo Carloni,Paolo Carloni +9 more
TL;DR: Recent advances in the use of molecular dynamics simulations and enhanced sampling methods for hCFP development are discussed from the viewpoints of scientists involved in both fields.
Journal ArticleDOI
Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection.
Shivan Chetty,Filippos Porichis,Pamla Govender,Jennifer Zupkosky,Musie Ghebremichael,Mona Pillay,Bruce D. Walker,Thumbi Ndung'u,Daniel Kaufmann,Victoria O. Kasprowicz +9 more
TL;DR: Tuberculosis disrupts the correlation between interleukin-10 and markers of HIV disease progression and is associated with a more inflammatory cytokine milieu compared with HIV monoinfection.
Journal ArticleDOI
Applications of SNAP-tag technology in skin cancer therapy.
Eden Padayachee,Henry A. Adeola,Jennifer C. Van Wyk,Fleury Augustine Nsole Biteghe,Shivan Chetty,Nonhlanhla P. Khumalo,Stefan Barth +6 more
TL;DR: Cancer treatment in the 21st century has seen immense advances in optical imaging and immunotherapy, with significant progress made in the bioengineering and production of immunoconjugates to achieve the goal of specifically targeting tumors.