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Bruce D. Walker
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 806
Citations - 94050
Bruce D. Walker is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Cytotoxic T cell & Epitope. The author has an hindex of 155, co-authored 779 publications receiving 86020 citations. Previous affiliations of Bruce D. Walker include University of Colorado Denver & University of Pittsburgh.
Papers
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Journal ArticleDOI
Hepatitis C Virus Infection
Georg M. Lauer,Bruce D. Walker +1 more
TL;DR: The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day,Daniel Kaufmann,Photini Kiepiela,Julia A. Brown,Eshia Moodley,Sharon Reddy,Elizabeth W Mackey,Joseph D. Miller,Alasdair Leslie,Chantal DePierres,Zenele Mncube,Jaikumar Duraiswamy,Baogong Zhu,Quentin Eichbaum,Marcus Altfeld,E. John Wherry,Hoosen M. Coovadia,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Paul Klenerman,Rafi Ahmed,Gordon J. Freeman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker +25 more
TL;DR: The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.
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Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Diana Finzi,Joel N. Blankson,Janet M. Siliciano,Joseph B. Margolick,Karen Chadwick,Theodore C. Pierson,Kendall A. Smith,Julianna Lisziewicz,Franco Lori,Charles Flexner,Thomas C. Quinn,Richard E. Chaisson,Eric S. Rosenberg,Bruce D. Walker,Stephen J. Gange,Joel E. Gallant,Robert F. Siliciano +16 more
TL;DR: The mean half-life of the latent reservoir was very long (43.9 months) and the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable as mentioned in this paper.
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Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
Eric S. Rosenberg,James M. Billingsley,Angela M. Caliendo,Steven L. Boswell,Paul E. Sax,Spyros A. Kalams,Bruce D. Walker +6 more
TL;DR: In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines.
Journal ArticleDOI
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
Franziska Lechner,David Wong,P R Dunbar,Roger W. Chapman,Raymond T. Chung,P B Dohrenwend,Gregory K. Robbins,Rodney E. Phillips,Paul Klenerman,Bruce D. Walker +9 more
TL;DR: A strong and persistent CTL response in resolving acute HCV infection is demonstrated, and rationale to explore immune augmentation as a therapeutic intervention in chronic HCv infection is provided.