https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–nitrogen bond formation are typically conducted at elevated temperatures, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of challenging carbon–carbon and carbon–heteroatom bonds. Here, electrosynthesis has proven to be an environmentally benign, highly effective and versatile platform for achieving a wide range of nonclassical bond disconnections via generation of radical intermediates under mild reaction conditions. This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon–hydrogen functionalization and carbon–nitrogen bond formation strategies. Emphasis is placed on methodology development and mechanistic insight and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.

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Electrochemical strategies for C-H functionalization and C-N bond formation.

Antituberculosis drugs: ten years of research.

▪ Abstract The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.

Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery

Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

Review: Marine natural products

Sesquiterpenes from Acorus calamus L.

Daphniphyllum alkaloids—II: Secodaphniphylline and methyl homosecodaphniphyllate

Biosynthesis of daphnilactone-B

Biosynthesis of daphniphyllum alkaloids

Germacrene-D, which has sexual attractant properties similar to those of periplanone-B, has been isolated in an optically impure state from many plants, i.e., (-) and (+)-germacrene-D co-occur in different ratios in various plants. (-)-Germacrene-D isolated from Solidago altissima L. in this work was determined to have an optical purity of 18.0%. In addition, the optical rotation of optically pure germacrene-D was estimated to be 305°.

Shosuke Yamamura

Papers

Sesquiterpenes from Acorus calamus L.

Daphniphyllum alkaloids—II: Secodaphniphylline and methyl homosecodaphniphyllate

Biosynthesis of daphnilactone-B

Biosynthesis of daphniphyllum alkaloids

Co-occurrence of (-) and (+)-Germacrene-D in Solidago altissima L. : Determination of the Optical Rotation of optically Pure Germacrene-D