https://bibliotecadigital.ipb.pt/bitstream/10198/8534/4/Ferreira%20FCT-D-12-01230%20Word%20original%20%20%20edits%20revised.pdf

A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives.

Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context. Situations in which AED measurements are most likely to be of benefit include (1) when a person has attained the desired clinical outcome, to establish an individual therapeutic concentration which can be used at subsequent times to assess potential causes for a change in drug response; (2) as an aid in the diagnosis of clinical toxicity; (3) to assess compliance, particularly in patients with uncontrolled seizures or breakthrough seizures; (4) to guide dosage adjustment in situations associated with increased pharmacokinetic variability (e.g., children, the elderly, patients with associated diseases, drug formulation changes); (5) when a potentially important pharmacokinetic change is anticipated (e.g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin.

/pdf/antiepileptic-drugs-best-practice-guidelines-for-therapeutic-2fvwrwdstw.pdf

Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

http://www.protocol-online.org/forums/uploads/monthly_07_2011/msg-6644-082599400%201311927155.ipb

Stationary and mobile phases in hydrophilic interaction chromatography: a review

Arbidol as a broad-spectrum antiviral: an update.

Particle packed columns and monolithic columns in high-performance liquid chromatography-comparison and critical appraisal.

A high-performance liquid chromatographic (HPLC) method is developed for the determination of the pharmacologically active terpenoids Ginkgolide A, B, and C and bilobalide in Ginkgo biloba L. leaves extract (GBE). The extracts are dissolved in methanol-water (1:4) and extracted by ethyl acetate after evaporation of the organic solvent, the residue is dissolved in methanol, and the terpenoids in the resultant solution are determined by means of HPLC on a C 1 8 column with methanol-water (23:77) as an eluent. The recovery provided by the method is above 96.5%, and the minimum concentration that can be determined is 80 μg of terpenoid per gram of GBE. The method is suitable for GBE production process control.

Shou-Zhuo Yao

Papers

High-Performance Liquid Chromatography