Shouqing Luo

TL;DR: Using immunoprecipitation experiments, it is shown that alpha Pix binds to both the N-terminal of wild-type htt (wthtt) and mutant htt (muthtt), which suggests thatalpha Pix plays an important role in muthtt aggregation.

TL;DR: This study suggests that production/accumulation of autophagosomes during lysosomal defect directly induces cellular toxicity, and this process may be implicated in the pathological conditions where lyssomes are defective.

TL;DR: Using pig model and human young permanent tooth pulp cells, this research has identified that the local anesthetics commonly used in clinics can affect cell proliferation and molecular pathway profiling suggested that LC3II is one of the earliest molecules induced by the agents and p62 is the only common downstream target identified for all the drugs tested.

TL;DR: The results suggest that artesunate or other inhibitors of lysosomal function would be potential in the treatment of cancer cells with drug resistance caused by the enhanced lysOSomal function.

TL;DR: It is shown that the levels of Bim, a BH3-only protein, are significantly increased in HD human post-mortem and HD mouse striata, correlating with neuronal death, which could contribute to the progression of HD.