S
Shrawan Baghel
Researcher at Waterford Institute of Technology
Publications - 6
Citations - 862
Shrawan Baghel is an academic researcher from Waterford Institute of Technology. The author has contributed to research in topics: Solubility & Amorphous solid. The author has an hindex of 5, co-authored 6 publications receiving 651 citations. Previous affiliations of Shrawan Baghel include Waterford Institute.
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Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs
TL;DR: This review attempts to address the critical molecular and thermodynamic aspects governing the physicochemical properties of amorphous solid dispersion systems and potential advantage of polymers as inert, hydrophilic, pharmaceutical carrier matrices.
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Theoretical and experimental investigation of drug-polymer interaction and miscibility and its impact on drug supersaturation in aqueous medium.
TL;DR: It has been found that drug-polymer combinations capable of hydrogen-bonding in the solution state are more effective in preventing drug crystallization compared to the drug- polymer systems without such interaction (CNZ-PVP), and DPM-PAA system outperformed all other ASDs in various stability conditions.
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Investigation into the Solid-State Properties and Dissolution Profile of Spray-Dried Ternary Amorphous Solid Dispersions: A Rational Step toward the Design and Development of a Multicomponent Amorphous System
TL;DR: A thorough investigation into the impact of combinations of additives on amorphous drug crystallization during dissolution and stability studies is recommended in order to develop optimized formulations of supersaturating dosage forms.
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An investigation into the crystallization tendency/kinetics of amorphous active pharmaceutical ingredients: A case study with dipyridamole and cinnarizine.
TL;DR: The calculated fragility, glass forming ability (GFA) and crystallization kinetics are found to be in good correlation with the stability prediction of amorphous solid dispersions.
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Understanding the generation and maintenance of supersaturation during the dissolution of amorphous solid dispersions using modulated DSC and 1H NMR.
TL;DR: It is established that the different drug/polymer interactions in the solid state and in solution give rise to the variation in dissolution profile observed for different systems, particularly in terms of inhibition of drug recrystallization and dissolution of DPM and CNZ ASDs.