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Shuaishuai Huang
Researcher at Ningbo University
Publications - 31
Citations - 214
Shuaishuai Huang is an academic researcher from Ningbo University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 8, co-authored 13 publications receiving 108 citations. Previous affiliations of Shuaishuai Huang include The University of Nottingham Ningbo China.
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Journal ArticleDOI
Cyclic AMP-Response Element Regulated Cell Cycle Arrests in Cancer Cells
TL;DR: It is demonstrated for the first time that specific cell cycle arrests in cancer cells can be induced by TCS by inhibiting the binding of CREB to CRE on genes related to cell proliferation.
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Decrease of phosphorylated proto-oncogene CREB at Ser 133 site inhibits growth and metastatic activity of renal cell cancer.
Xue Wang,Yu Ren,Haihui Zhuang,Xiangyu Meng,Shuaishuai Huang,Yanyuan Li,Michael Hehir,Ping Wang +7 more
TL;DR: Investigation of the role of phosphorylated CREB at Ser133 in renal cell carcinoma (RCC) growth and metastases suggests that decreasing the level of pCREB inhibits the growthand metastasis of RCC by targeting the Ser 133 site.
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Application of Ultrasound-Targeted Microbubble Destruction-Mediated Exogenous Gene Transfer in Treating Various Renal Diseases.
TL;DR: The mechanisms and applications of UTMD in terms of renal disease, including diabetic nephropathy, renal carcinoma, acute kidney injury, renal interstitial fibrosis, nephrotoxic nephritis, urinary stones, and acute rejection are reviewed.
Journal ArticleDOI
The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ.
Xue Wang,Xue Wang,Shuaishuai Huang,Shuaishuai Huang,Xia Xin,Yu Ren,Yu Ren,Guobin Weng,Guobin Weng,Ping Wang +9 more
TL;DR: The results have revealed that treatment of human RCC cells with umbelliferone reduced cell proliferation in a concentration-dependent manner and induced dose-dependent apoptotic events, and insight is provided into the pharmacology regarding the potential application of umbeliferone, which contributes to cell death by decreasing p110γ protein expression.
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Cyclic AMP responsive element-binding protein induces metastatic renal cell carcinoma by mediating the expression of matrix metallopeptidase-2/9 and proteins associated with epithelial-mesenchymal transition
TL;DR: The results of the present study indicate that CREB regulated metastatic RCC by mediating the expression of MMP‐2/9 and EMT‑associated proteins, however, CREB‑mediated MMP‑2/ 9 and E MT‑associated protein expression may be induced by different pathways in different RCC cells.