Shuangping Huang

TL;DR: In this paper, a concise and straightforward total synthetic approach towards lycorine-type alkaloid (−)-γ-lycorane has been achieved in 7 steps using a palladium-catalyzed aromatic C H alkylation of unactivated secondary alkyl iodide.

TL;DR: In this article, a concise total synthesis of (+)-brazilin from readily available 4-bromo-1,2-dimethoxybenzene was described, where a Sharpless asymmetric dihydroxylation was employed to introduce the chiral hydroxyl group and trifluoroacetic acid (TFA) catalyzed one-pot intramolecular tandem Prins/Friedel-Crafts reaction was also involved as the key transformation in the construction of the hybrid chromane and indane framework.

TL;DR: In this article, N-Alkyl nitrones are used as the starting materials to construct various N-aryl isoxazolidines, instead of N-alkyl isoxozolidines or N-H 1,3-oxazinanes via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins.

TL;DR: In this article, the authors describe a new and straightforward approach to the formal synthesis of entecavir, an important hepatitis B drug, in ten steps overall, using a Morita-Baylis-Hillman reaction, a Sharpless asymmetric epoxidation, a reductive epoxide opening of an α,β-epoxy ketone, and a Riley selenium dioxide oxidation.

TL;DR: In this article, a unified asymmetric total synthesis of (+)-porantheridine and (−)-6-epi-PORANTHERidine has been achieved via a Horner-Wadsworth-Emmons/aza-Michael addition reaction or diastereoselective nucleophilic substitution of 2-methoxypiperidine from a common intermediate.