Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

2.5. Ionic Liquids Presented in This Review 2020 3. Cyclocondensation Reactions 2020 4. Synthesis of Three-Membered Heterocycles 2022 4.1. Aziridines 2022 5. Synthesis of Five-Membered Heterocycles 2022 5.1. Pyrroles 2022 5.2. Furans 2022 5.3. Thiophenes 2023 5.4. Pyrazoles 2024 5.5. Imidazoles 2025 5.6. Isoxazoles 2027 5.7. Oxazoles, Oxazolines, and Oxazolidinones 2027 5.8. Thiazoles and Thiazolidinones 2028 6. Synthesis of Six-Membered Heterocycles 2030 6.1. Pyridines 2030 6.2. Quinolines 2031 6.3. Acridines 2033 6.4. Pyrans 2033 6.5. Flavones 2035 6.6. Pyrimidines and Pyrimidinones 2035 6.7. Quinazolines 2037 6.8. -Carbolines 2038 6.9. Dioxanes 2039 6.10. Oxazines 2039 6.11. Benzothiazines 2040 6.12. Triazines 2040 7. Synthesis of Seven-Membered Heterocycles: Diazepines 2041

Ionic liquids in heterocyclic synthesis.

Utilisation of 1,3‐Dicarbonyl Derivatives in Multicomponent Reactions

As two coexisting and fast-growing research fields in modern synthetic chemistry, the merging of organocatalysis and C–H bond functionalization is well foreseeable, and the joint force along this line has been demonstrated to be a powerful approach in making inert C–H bond functionalization more viable, predictable, and selective. In this review, we provide a comprehensive summary of organocatalysis in inert C–H bond functionalization over the past two decades. The review is arranged by types of inert C–H bonds including alkane C–H, arene C–H, and vinyl C–H as well as those activated benzylic C–H, allylic C–H, and C–H bonds alpha to the heteroatom such as nitrogen and oxygen. In each section, the discussion is classified by the explicit organocatalytic mode involved.

Organocatalysis in Inert C–H Bond Functionalization

A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs2CO3 in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15−24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon−amino function have been controlled completely. The stereochemistry has been unequivocally determined by X-ray structural analysis. The resulting tricyclo[6.2.2.01,6]dodecane derivatives are of importance for organic and medicinal research.

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Four-Component Domino Reaction Providing an Easy Access to Multifunctionalized Tricyclo[6.2.2.01,6]dodecane Derivatives

https://www.rsc.org/suppdata/cc/c4/c4cc06795a/c4cc06795a1.pdf

Selective sulfonylation and diazotization of indoles

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives. This synthesis was performed using potassium hydrogen sulfate as the promoter in glycol solution. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (85-99%) and short reaction time (0.5-2 h).

A New Biginelli Reaction Procedure Using Potassium Hydrogen Sulfate as the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-one

A novel sequential addition, elimination and cyclization reactions took place when aldoxime and dimedone in glycol was subjected to microwave irradiation and a new type of N-hydroxyl-acridinedione derivatives was obtainedin excellent yields (80-95%) within a short reaction time (4-8 min).

Shujiang Tu

Papers

Four-Component Domino Reaction Providing an Easy Access to Multifunctionalized Tricyclo[6.2.2.01,6]dodecane Derivatives

Selective sulfonylation and diazotization of indoles

A New Biginelli Reaction Procedure Using Potassium Hydrogen Sulfate as the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-one

A novel cascade reaction of aryl aldoxime with dimedone under microwave irradiation: The synthesis of N-hydroxylacridine

New potential inhibitors of cyclin-dependent kinase 4: design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation.