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Shunying Jin
Researcher at University of Louisville
Publications - 7
Citations - 556
Shunying Jin is an academic researcher from University of Louisville. The author has contributed to research in topics: Transforming growth factor & Bronchoalveolar lavage. The author has an hindex of 5, co-authored 7 publications receiving 427 citations.
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Journal ArticleDOI
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.
Shu G. Chen,Vilius Stribinskis,Madhavi J. Rane,Donald R. Demuth,Evelyne Gozal,Andrew M. Roberts,Rekha Jagadapillai,Ruolan Liu,Kyonghwan Choe,Bhooma Shivakumar,Francheska Son,Shunying Jin,Richard A. Kerber,Anthony Adame,Eliezer Masliah,Robert P. Friedland +15 more
TL;DR: It is suggested that bacterial amyloid functions as a trigger to initiate AS aggregation through cross-seeding and also primes responses of the innate immune system.
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Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
Madhavi J. Rane,Ye Song,Shunying Jin,Michelle T. Barati,Rui Wu,Hina Kausar,Yi Tan,Yi Tan,Yuehui Wang,Guihua Zhou,Jon B. Klein,Xiaokun Li,Lu Cai,Lu Cai +13 more
TL;DR: Mechanism of downregulation of Akt activation in 6-mo streptozotocin diabetic kidneys was attributed to decreased Akt-heat shock protein (Hsp) 25,Akt-p38 interaction, and decreased PTEN activity, suggesting PTEN or Hsp25 could serve as potential therapeutic targets to modulate Aktactivation and control p38 MAPK-mediated diabetic complications.
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Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer
TL;DR: Combined WFA with Dox decreases the dosage requirement of Dox, therefore, minimizing/eliminating the severe side effects associated with high doses of DOX, suggesting the application of this combination strategy for the treatment of ovarian and other cancers with no or minimum side effects.
Journal ArticleDOI
Inhibition of Neutrophil Exocytosis Ameliorates Acute Lung Injury in Rats
Silvia M. Uriarte,Madhavi J. Rane,Michael L. Merchant,Shunying Jin,Alex B. Lentsch,Richard A. Ward,Kenneth R. McLeish +6 more
TL;DR: Results indicate that administration of a TAT-fusion protein that inhibits neutrophil exocytosis reduces in vivo ALI, a potential therapeutic strategy to ameliorate ALI.
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Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.
Shunying Jin,Michael L. Merchant,Jeffrey D. Ritzenthaler,Kenneth R. McLeish,Eleanor D. Lederer,Edilson Torres-Gonzalez,Mostafa Fraig,Michelle T. Barati,Alex B. Lentsch,Jesse Roman,Jon B. Klein,Jon B. Klein,Madhavi J. Rane +12 more
TL;DR: GABR2 expression was regulated in the type II pneumocytes in lung tissue sections from lung injured patients, further suggesting a physiological role for GABABR2 in the repair process of lung damage.