Bone tissue is a complex biocomposite material with a variety of organic (e.g., proteins, cells) and inorganic (e.g., hydroxyapatite crystals) components hierarchically organized with nano/microscale precision. Based on the understanding of such hierarchical organization of bone tissue and its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for the successful designing of complex, hybrid biomaterials is the facilitation and control of adhesion at the interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, researchers have focused on controlling the interface by surface modifications, but the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials remains a critical challenge. Here, a universal biomineralization route, called polydopamine-assisted hydroxyapatite formation (pHAF), that can be applied to virtually any type and morphology of scaffold materials is demonstrated. Inspired by the adhesion mechanism of mussels, the pHAF method can readily integrate hydroxyapatites on ceramics, noble metals, semiconductors, and synthetic polymers, irrespective of their size and morphology (e.g., porosity and shape). Surface-anchored catecholamine moieties in polydopamine enriches the interface with calcium ions, facilitating the formation of hydroxyapatite crystals that are aligned to the c-axes, parallel to the polydopamine layer as observed in natural hydroxyapatites in mineralized tissues. This universal surface biomineralization can be an innovative foundation for future tissue engineering.

Mussel-Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization

http://repository.ust.hk/ir/bitstream/1783.1-2183/1/JBMT915text.pdf

Theoretical analysis of calcium phosphate precipitation in simulated body fluid

Biomimetic apatite formation on chemically treated titanium.

Biomineralization Ability and Interaction of Mineral Trioxide Aggregate and White Portland Cement With Dentin in a Phosphate-containing Fluid

https://www.tpbin.com/Uploads/Subjects/7f75011f-fae9-4044-8f76-8ee086d5b01f.pdf

Shuxin Qu

Papers

TEM study of calcium phosphate precipitation on HA/TCP ceramics

TEM examination of single crystal hydroxyapatite diffraction

Effect of the crystallinity of calcium phosphate ceramics on osteoblast proliferation in vitro

Histological and ultrastructural analysis of heterotopic osteogenesis in porous calcium phosphate ceramics

TEM Examinations of Calcium Phosphate Precipitation on HA/TCP