S
Shuyuan Yeh
Researcher at University of Rochester Medical Center
Publications - 235
Citations - 16332
Shuyuan Yeh is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Androgen receptor & Prostate cancer. The author has an hindex of 64, co-authored 221 publications receiving 14658 citations. Previous affiliations of Shuyuan Yeh include Tianjin Medical University & University of Rochester.
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Journal ArticleDOI
Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
Shuyuan Yeh,Meng Yin Tsai,Meng Yin Tsai,Qingquan Xu,Xiao Min Mu,Henry A. Lardy,Ko En Huang,Hank Lin,Shauh Der Yeh,Saleh Altuwaijri,Xinchang Zhou,Lianping Xing,Brendan F. Boyce,Mien Chie Hung,Su Zhang,Lin Gan,Chawnshang Chang +16 more
TL;DR: The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice, suggesting potential defects in female fertility and/or ovulation.
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Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
Shuyuan Yeh,Chawnshang Chang +1 more
TL;DR: Using a yeast two-hybrid system, a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10) M dihydrotestosterone or 10(-9) M testosterone, is isolated.
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From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
TL;DR: It is demonstrated that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu, and this may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients.
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Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
Chawnshang Chang,Yen-Ta Chen,Yen-Ta Chen,Shauh-Der Yeh,Qingquan Xu,Ruey-Sheng Wang,Ruey-Sheng Wang,Florian Guillou,Henry A. Lardy,Shuyuan Yeh +9 more
TL;DR: In vivo evidence is provided of the need for functional AR in Sertoli cells to maintain normal spermatogenesis and testosterone production, and ensure normal male fertility.
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Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice
TL;DR: This review tries to clarify the useful information regarding how androgen/AR functions in individual cells of the testis by comparing the results of cell-specific AR knockout in germ cells, peritubular myoid cells, Leydig cells, and Sertoli cells mouse models that were generated by different laboratories to see the consequent defects in spermatogenesis due to AR loss in different testicular cell types in s permatogenesis.