S
Shweta Agarwal
Researcher at Council of Scientific and Industrial Research
Publications - 13
Citations - 301
Shweta Agarwal is an academic researcher from Council of Scientific and Industrial Research. The author has contributed to research in topics: Nitrosourea & Nimustine. The author has an hindex of 9, co-authored 13 publications receiving 260 citations. Previous affiliations of Shweta Agarwal include Banaras Hindu University & Academy of Scientific and Innovative Research.
Papers
More filters
Journal ArticleDOI
Spectroscopic studies of the effects of anticancer drug mitoxantrone interaction with calf-thymus DNA
TL;DR: The capability of spectroscopic analysis to characterize the nature of drug-biomolecule complex and the effects of such interaction on the structure of biomolecule is shown.
Journal ArticleDOI
Spectroscopic analysis of the interaction of lomustine with calf thymus DNA.
TL;DR: Spectroscopic results confirm the formation of an intermediate stage of DNA that occurs during the transition of B-conform into A-conformation, and show perturbation in the local conformation of DNA upon binding of lomustine with DNA helix.
Journal ArticleDOI
Molecular modeling and spectroscopic studies of semustine binding with DNA and its comparison with lomustine-DNA adduct formation.
TL;DR: Results of the present study demonstrate that semustine performs major-groove-directed DNA alkylation at guanine residues in an incubation-time–drug-concentration-dependent manner, which may establish a correlation between molecular structure and cytotoxicity of chloroethyl nitrosourea therapeutics possessing better efficacy and fewer side effects.
Journal ArticleDOI
A structural insight into major groove directed binding of nitrosourea derivative nimustine with DNA: a spectroscopic study.
TL;DR: Results of the present study demonstrate that nimustine is not a simple alkylating agent rather it causes major grove-directed-alkylation, which may contribute in the development of new nitrosourea therapeutics with better efficacy and fewer side effects.
Journal ArticleDOI
Interaction Studies of Anticancer Drug Lomustine with Calf Thymus DNA using Surface Enhanced Raman Spectroscopy
TL;DR: Results suggest binding of lomustine with nitrogenous bases guanine and cytosine alongwith weak interaction to the sugar–phosphate backbone of DNA may support rational drug designing efforts to develop nitrosourea based novel therapeutics.