Si Lok

TL;DR: A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.

TL;DR: Alignment of the amino acid sequences of the four mouse gamma-crystallins according to the known four structural motifs of the major calf gamma- Crystallin, gamma-II, suggests that all four mouse polypeptides are structurally very similar to calf Gamma-II; however, most of the mouse polyPEptides differ from gamma- II by the absence of one amino acid residue, resulting in a shorter connecting peptide between the two globular domains of the protein.

TL;DR: It is shown that a cloned mouse gamma-crystallin promoter is active in lens explants derived from 14-day-old chicken embryos but inactive in a variety of cells of non-lens origin.

TL;DR: A highly conserved region, 50 nucleotides in length, immediately precedes the TATA box of both the mouse and rat genes, suggesting that this sequence may be important in gene regulation.

TL;DR: While the different γ-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development.