N
Natasa Plavsic
Researcher at University of Toronto
Publications - 8
Citations - 7356
Natasa Plavsic is an academic researcher from University of Toronto. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Locus (genetics). The author has an hindex of 6, co-authored 8 publications receiving 7134 citations.
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Journal ArticleDOI
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
John R. Riordan,Johanna M. Rommens,Batsheva Kerem,Noa Alon,Richard Rozmahel,Zbyszko Grzelczak,Julian Zielenski,Si Lok,Natasa Plavsic,Jia Ling Chou,Mitchell L. Drumm,Michael C. Iannuzzi,Francis S. Collins,Lap-Chee Tsui +13 more
TL;DR: A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.
Journal ArticleDOI
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker
Lap-Chee Tsui,Manuel Buchwald,D. Barker,Jeffrey C. Braman,Robert G. Knowlton,James W. Schumm,Hans Eiberg,Jan Mohr,Dara Kennedy,Natasa Plavsic,Martha Zsiga,Danuta Markiewicz,Gita Akots,Valerie K. Brown,Cynthia Helms,Thomas C. Gravius,Carol A. Parker,Kenneth S. Rediker,Helen Donis-Keller +18 more
TL;DR: The discovery of a linked DNA polymorphism is the first step in molecular analysis of the CF gene and its causative role in the disease.
Journal Article
Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.
Johanna M. Rommens,Zengerling S,Julie E. Burns,Georg Melmer,Batsheva Kerem,Natasa Plavsic,Martha Zsiga,Dara Kennedy,Danuta Markiewicz,Richard Rozmahel,Jack R. Riordan,Manuel Buchwald,Lap-Chee Tsui +12 more
TL;DR: Family and physical mapping studies showed that two of the DNA markers, D7S122 and D7s340, are in close linkage with CF, and reaffirms the general strategy in approaching a disease locus on the basis of chromosome location.
Journal ArticleDOI
Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator.
Tohru Yorifuji,Wanda K. Lemna,Cara F. Ballard,Craig L. Rosenbloom,Richard Rozmahel,Natasa Plavsic,Lap-Chee Tsui,Arthur L. Beaudet,Arthur L. Beaudet +8 more
TL;DR: Comparison of the deduced amino acid sequence showed that the mouse protein has high homology to the human protein, and the amino acid identity was high for both transmembrane domains and for both ATP-binding folds, suggesting the functional importance of these regions.
Book ChapterDOI
Molecular genetics of cystic fibrosis.
Lap-Chee Tsui,Johanna M. Rommens,Batsheva Kerem,Richard Rozmahel,Julian Zielenski,Dara Kennedy,Danuta Markiewicz,Natasa Plavsic,J.-L. Chou,Dominique Bozon,M. Dobbs +10 more
TL;DR: The gene for cystic fibrosis (CF) has recently been isolated (Rommens et al., 1989a), rendering it possible for the first time to study the elusive symptoms of the disease.