S
Si Lok
Researcher at University of Toronto
Publications - 6
Citations - 6977
Si Lok is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 5, co-authored 5 publications receiving 6753 citations.
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Journal ArticleDOI
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
John R. Riordan,Johanna M. Rommens,Batsheva Kerem,Noa Alon,Richard Rozmahel,Zbyszko Grzelczak,Julian Zielenski,Si Lok,Natasa Plavsic,Jia Ling Chou,Mitchell L. Drumm,Michael C. Iannuzzi,Francis S. Collins,Lap-Chee Tsui +13 more
TL;DR: A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.
Journal ArticleDOI
Gamma-crystallin family of the mouse lens: structural and evolutionary relationships
Martin L. Breitman,Si Lok,Graeme Wistow,Joram Piatigorsky,Jacques A. Tréton,Reynold J. M. Gold,Lap-Chee Tsui +6 more
TL;DR: Alignment of the amino acid sequences of the four mouse gamma-crystallins according to the known four structural motifs of the major calf gamma- Crystallin, gamma-II, suggests that all four mouse polypeptides are structurally very similar to calf Gamma-II; however, most of the mouse polyPEptides differ from gamma- II by the absence of one amino acid residue, resulting in a shorter connecting peptide between the two globular domains of the protein.
Journal ArticleDOI
Lens-specific promoter activity of a mouse gamma-crystallin gene.
Si Lok,Martin L. Breitman,A. B. Chepelinsky,Joram Piatigorsky,Reynold J. M. Gold,Lap-Chee Tsui +5 more
TL;DR: It is shown that a cloned mouse gamma-crystallin promoter is active in lens explants derived from 14-day-old chicken embryos but inactive in a variety of cells of non-lens origin.
Journal ArticleDOI
Analysis of the mouse γ-crystallin gene family: assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative gene
Si Lok,Lap-Chee Tsui,Toshimichi Shinohara,Joram Piatigorsky,Reynold J. M. Gold,Martin L. Breitman +5 more
TL;DR: A highly conserved region, 50 nucleotides in length, immediately precedes the TATA box of both the mouse and rat genes, suggesting that this sequence may be important in gene regulation.
Journal ArticleDOI
Differential regulation of γ-crystallin genes during mouse lens development☆
Manuela Murer-Orlando,Roger C. Paterson,Si Lok,Lap-Chee Tsui,Martin L. Breitman,Martin L. Breitman +5 more
TL;DR: While the different γ-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development.