S
Sigrid Scheek
Researcher at University of Texas Southwestern Medical Center
Publications - 2
Citations - 327
Sigrid Scheek is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Sterol regulatory element-binding protein & Golgi apparatus. The author has an hindex of 2, co-authored 2 publications receiving 321 citations.
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Journal ArticleDOI
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.
TL;DR: It is suggested that sterols regulate the cleavage of SREBPs by modulating the ability of SCAP to transport S REBPs to a post-ER compartment that houses active Site-1 protease.
Journal ArticleDOI
Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1
TL;DR: Results indicate that cells regulate the balance between cholesterol and sphingomyelin content by regulating the proteolytic cleavage of SREBPs.