Silvia D'Arezzo

TL;DR: It is shown here for the first time that transduction of the hormone signal in this nongenomic response requires tyrosine kinase-dependent phospholipase C activation and two different signaling pathways: mobilization of intracellular calcium and protein phosphorylation involving protein kinase C and MAPK (ERK1/2).

TL;DR: In this article, the in vitro interaction of tigecycline with seven commonly used anti-Acinetobacter drugs has been assessed, and the results showed that the combination therapy provided new hope for the treatment of MDR A. baumannii infections.

TL;DR: Comparative analysis revealed that in pABVA01, blaOXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

TL;DR: The authors' results are consistent with the hypothesis that patients became indirectly infected, e.g., during central venous catheter handling through contaminated items, and that the triclosan soap dispenser acted as a common continuous source of P. aeruginosa infection.

TL;DR: Molecular typing showed that the epidemic lineage encoding OXA-23 emerged in 2007 and displaced a genetically related clone encoding OxA-58 that had been responsible for previous ICU outbreaks in the same region.