S
Silvia Marino
Researcher at Queen Mary University of London
Publications - 306
Citations - 10559
Silvia Marino is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 40, co-authored 264 publications receiving 9252 citations. Previous affiliations of Silvia Marino include University of Manchester & University of Zurich.
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
TL;DR: This work shows that bmi-1-deficient primary mouse embryonic fibroblasts are impaired in progression into the S phase of the cell cycle and undergo premature senescence, and connects transcriptional repression by Polycomb-group proteins with cell-cycle control and senescences.
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Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
TL;DR: It is demonstrated that loss of function of RB is essential for medulloblastoma development in the mouse and strongly support the hypothesis that medullOBlastomas arise from multipotent precursor cells located in the EGL.
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Normal host prion protein necessary for scrapie-induced neurotoxicity
Sebastian Brandner,Stefan Isenmann,Alex Raeber,Marek Fischer,Andreas W. Sailer,Yasushi Kobayashi,Silvia Marino,Charles Weissmann,Adriano Aguzzi +8 more
TL;DR: In addition to being resistant to scrapie infection, brain tissue devoid of PrPc is not damaged by exogenous PrPSc, and even 16 months after inoculation no pathological changes were seen in PrP-deficient tissue, not even in the immediate vicinity of the grafts.
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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
Carly Leung,Merel Lingbeek,Olga Shakhova,James K. Liu,Ellen Tanger,Parvin Saremaslani,Maarten van Lohuizen,Silvia Marino +7 more
TL;DR: The findings implicate BMI1 overexpression as an alternative or additive mechanism in the pathogenesis of medulloblastomas, and highlight a role for Bmi1-containing polycomb complexes in proliferation of cerebellar precursor cells.
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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
Jan Willem Voncken,Bernard A.J. Roelen,Mieke Roefs,Stijn de Vries,E. Verhoeven,Silvia Marino,J. Deschamps,Maarten van Lohuizen +7 more
TL;DR: It is shown that the early developmental arrest in Rnf2-null embryos is partially bypassed by genetic inactivation of the Cdkn2a (Ink4a/ARF) locus, which implicates Polycomb-mediated repression of the Bmi1 locus in early murine development.