Bernard A.J. Roelen

TL;DR: Ch Chimera analysis indicates that it is the Bmp4 expression in the extraembryonic ectoderm that regulates the formation of allantois and primordial germ cell precursors, and the size of the founding population of PGCs.

TL;DR: It is shown here that SOST/sclerostin is expressed exclusively by osteocytes in mouse and human bone and inhibits the differentiation and mineralization of murine preosteoblastic cells (KS483) and its unique localization and action on osteoblasts suggest that sclerost in may be the previously proposed osteocyte-derived factor that is transported to osteoblast at the bone surface and inhibits bone formation.

TL;DR: It is shown that the early developmental arrest in Rnf2-null embryos is partially bypassed by genetic inactivation of the Cdkn2a (Ink4a/ARF) locus, which implicates Polycomb-mediated repression of the Bmi1 locus in early murine development.

TL;DR: A striking inverse relationship between cardiomyocyte differentiation and the concentration of FCS is demonstrated during HES‐2‐END‐2 coculture, and this model represents an improved in vitro model, without interfering factors in serum, for testing other factors that might promote cardiomeocyte differentiation.

TL;DR: Findings suggest a novel pathological pathway that unifies maternal and embryonic causes of RPL, and postulated that impaired embryo recognition and selection would clinically be associated with increased fecundity, defined by short time-to-pregnancy (TTP) intervals.