Simon J. Cook

TL;DR: A detailed phylogenetic analysis for mammalian members of the family Herpesviridae, based on molecular sequences is reported, finding that major sublineages within subfamilies were probably generated before the mammalian radiation of 80 to 60 million years ago, and that speciations within sub lineages took place in the last 80 million years, probably with a major component of cospeciation with host lineages.

TL;DR: It was estimated that the two mammalian alphaherpesvirus groups diverged around the period of the mammalian radiation, and that alphaherpeviral genome sequences have evolved faster than those of mammals by a factor of one to two orders of magnitude.

TL;DR: The results suggest that stimulation of the cells with either bombesin or TPA activates phospholipase D-catalysed phosphatidylcholine breakdown by a common mechanism involving the activation of protein kinase C.

TL;DR: Platelet-derived growth factor stimulated sn-1,2-diacylglycerol (DAG) mass formation in Swiss 3T3 fibroblasts with a lag time of some 30 s, suggesting that DAG is derived from PtdIns(4,5)P2 hydrolysis at this time point, and down-regulation of protein kinase C by pre-treatment with phorbol 12-myristate 13-acetate abolished both choline

TL;DR: Addition of epidermal growth factor to quiescent Swiss 3T3 cells resulted in a sustained increase in cellular diacylglycerol (DG) content in the absence of inositol-lipid hydrolysis, suggesting a role for a coupled PLD/phosphatidate phosphohydrolase pathway.