S
Sina Shadfar
Researcher at Macquarie University
Publications - 21
Citations - 529
Sina Shadfar is an academic researcher from Macquarie University. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 9, co-authored 16 publications receiving 351 citations. Previous affiliations of Sina Shadfar include Islamic Azad University & Yeungnam University.
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Journal ArticleDOI
Motor Neuron Susceptibility in ALS/FTD.
TL;DR: The anatomical network and neuronal microenvironment as determinants of MN subtype vulnerability and hence the progression of ALS are reviewed.
Journal ArticleDOI
Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease.
Nikita Katila,Sunil Bhurtel,Sina Shadfar,Sunil Srivastav,Sabita Neupane,Uttam Ojha,Gil-Saeng Jeong,Dong-Young Choi +7 more
TL;DR: The results indicate that metformin provides neuroprotection against MPTP neurotoxicity, which might be mediated by inhibition of α-synuclein phosphorylation and induction of neurotrophic factors.
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Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents
TL;DR: Supportive evidence that neuroinflammation plays a critical role in AD development is focused on and putative therapeutic capacity of anti-inflammatory drugs for AD prevention or treatment is depicted.
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Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
Anna Konopka,Donna R. Whelan,Shafi Jamali,Emma R. Perri,Hamideh Shahheydari,Reka P. Toth,Sonam Parakh,Tina Robinson,Alison Cheong,Prachi Mehta,Marta Vidal,Audrey Ragagnin,Ivan Khizhnyak,Cyril J. Jagaraj,Jasmin Galper,Natalie Grima,Anand K. Deva,Sina Shadfar,Garth A. Nicholson,Garth A. Nicholson,Shu Yang,Suzanne M. Cutts,Zuzana Horejsi,Toby D. M. Bell,Adam K. Walker,Adam K. Walker,Ian P. Blair,Julie D. Atkin,Julie D. Atkin +28 more
TL;DR: It is revealed that TDP-43 functions in DNA repair, but loss of this function triggers DNA damage and is associated with key pathological features of ALS.
Journal ArticleDOI
Neuroprotective Effects of Antidepressants via Upregulation of Neurotrophic Factors in the MPTP Model of Parkinson’s Disease
Sina Shadfar,Yu-Gyeong Kim,Nikita Katila,Sabita Neupane,Uttam Ojha,Sunil Bhurtel,Sunil Srivastav,Gil-Saeng Jeong,Pil-Hoon Park,Jin Tae Hong,Dong-Young Choi +10 more
TL;DR: It was found that fluoxetine and imipramine are more potent in raising the levels of neurotrophic factors than milnacipran, and neuroprotection of the antidepressants against 1-methyl-4-phenylpyridinium neurotoxicity in SH-SY5Y cells was attenuated by ERK or Akt inhibitor.