The present invention provides an iodine-based solution, and a method of using that solution, which sterilizes tissue implants without denaturing the proteins in the implant and without inducing calcification of the implant in vivo. Preferably, the tissue implants sterilized using the present invention are fixed without using glutaraldehyde. Most preferably, the tissue implants are fixed by photooxidation.

Sterilization of tissue implants using iodine

A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the incorporation of biocompatible polymers into the tissue in an amount effective in reducing calcification of the implanted tissue.

Polymer incorporation into implantable biological tissue to inhibit calcification

A process for the preparation of implantable biological tissue wherein elastomeric copolymers are incorporated into the tissue in an amount sufficient to increase the durability of the tissue as well as to reduce calcification of the tissue upon implantation. Mitigaton of calcification is retained when the tissue is subjected to flexing, stretching, or similar motion.

Elastomeric polymer incorporation into implantable biological tissue to inhibit calcification

A process for selectively incorporating biocompatible polymers in the interstices of implantable biological tissue while leaving the outer surface of the tissue substantially free of bonded polymer. The process involves covalently binding a monomer to the tissue, contacting the tissue with a free-radical initiator, then contacting the tissue with a solution containing a second monomer and a free-radical scavenger, thereby promoting selective polymerization of the second monomer with the portion of covalently-bound first monomer which is located in the interstices of the tissue.

Selective incorporation of a polymer into implantable biological tissue to inhibit calcification

Die Erfindung betrifft wasserlosliche, saure Gruppen enthaltende Pfropf-Copolymerisate mit zumindest teilweise biologischer Abbaubarkeit auf der Basis von Zuckern und monoethylenisch ungesattigten Carbonsauren, Sulfonsauren und/oder Phosphonsauren oder den Salzen dieser Sauren sowie die ggf. weiteren Monomeren. Die Erfindindung betrifft ferner ein Verfahren zur Herstellung dieser Pfropf-Copolymerisate bei Temperaturen bis 200 °C mittels radikalischer Polymerisationsinitatioren, indem eine Gesamtmischung aus 5-60 Gew. % Mono-, Di- und Olygosacchariden, deren Derivaten oder deren Mischungen und 95-40 Gew. % einer Monomermischung, die wenigstens eine monoethylenisch ungesattigte Carbonsaure, wenigstens eine monoethylenisch ungesattigte Sulfonsaure, einen monoethylenisch ungesattigten Schwefelsaureester und/oder Vinylphosphonsaure oder die Salze dieser Sauren mit einwertigen Kationen sowie ggf. weitere Monomere enthalt, polymerisiert wird. Ferner betrifft die Erfindung die Verwendung der Pfropf-Copolymerisate in wasrigen Systemen zur Bindung con mehrwertigen Metallionen, zur Inhibierung der Wasserharte, als Zusatz zu Wasch- und Reinigungsmitteln, als Textilhilfsmittel, Dispergiermittel, insbesondere fur Pigmente sowie als Hilfsmittel bei der Papier- und Lederherstellung.

Pfropf-copolymerisate von ungesättigten monomeren und zuckern, verfahren zu ihrer herstellung und ihre verwendung

What is disclosed are a method for treating pelts or leather in the beamhouse, for tanning, or as an aftertreatment, which method comprises contacting said pelts or leather with an aqueous solution or dispersion of a copolymer comprising monomers of a nitrogenous ester of acrylic acid or of methacrylic acid, a further different ester of acrylic acid or of methacrylic acid, and acrylic acid or methacrylic acid, whereby portions of said copolymer are deposited in the grain layer without formation of a superficial film, and pelts and leather treated by this method.

Siol Werner

Papers

Method for treating pelts and leather

Produits polymeres servant au traitement des peaux en tripes et des cuirs et utilisations de ces produits dans un tel traitement

Polymerprodukte zur behandlung von bloessen und leder