S
Soheila Swanton
Researcher at University of Cambridge
Publications - 5
Citations - 3561
Soheila Swanton is an academic researcher from University of Cambridge. The author has contributed to research in topics: Chromosome 20 & Myeloid. The author has an hindex of 4, co-authored 5 publications receiving 3402 citations.
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Journal ArticleDOI
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
E. Joanna Baxter,Linda M. Scott,Peter J. Campbell,Clare L. East,Nasios Fourouclas,Soheila Swanton,George S. Vassiliou,Anthony J. Bench,Elaine M. Boyd,Natasha Curtin,Michael A. Scott,Wendy N. Erber,Anthony R. Green,Anthony R. Green +13 more
TL;DR: A single acquired mutation of JAK2 was noted in more than half of patients with a myeloproliferative disorder and its presence in all erythropoietin-independent erythroid colonies demonstrates a link with growth factor hypersensitivity, a key biological feature of these disorders.
Journal ArticleDOI
Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes. UK Cancer Cytogenetics Group (UKCCG).
Anthony J. Bench,Elisabeth P. Nacheva,Tracey L. Hood,Jane L. Holden,Lisa French,Soheila Swanton,Kim Champion,Juan Li,Pamela Whittaker,George Stavrides,Adrienne Hunt,Brian Jp Huntly,Lynda J. Campbell,David R. Bentley,Panos Deloukas,Anthony R. Green +15 more
TL;DR: Analysis of patients with a 20q deletion associated with a myeloid malignancy identifies a set of genes which are both positional and expression candidates for the target gene(s) on 20q, which is the most detailed physical map of this region to date.
Journal ArticleDOI
Size matters: the prognostic implications of large and small deletions of the derivative 9 chromosome in chronic myeloid leukemia
Nasios Fourouclas,Peter J. Campbell,A Bench,Soheila Swanton,E J Baxter,Brian J. P. Huntly,Anthony R. Green +6 more
TL;DR: The results support the tumor suppressor gene model for the pathogenesis of der(9) deletions, argue against alternative models and provide insight into candidate gene location.
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An acquired translocation in JAK2 Val617Phe-negative essential thrombocythemia associated with autosomal spread of X-inactivation.
George S. Vassiliou,Peter J. Campbell,Juan Li,Irene Roberts,Soheila Swanton,Brian J. P. Huntly,Nasios Fourouclas,E J Baxter,LR Munro,DA Culligan,Linda M. Scott,Anthony R. Green +11 more
TL;DR: It is shown that this is the first documented example of autosomal gene silencing adjacent to an X-autosome breakpoint in human malignancy and such a mechanism may underlie the pathogenesis of related disorders with translocations involving Xq13.
Journal ArticleDOI
Double Philadelphia masquerading as chromosome 20q deletion - A new recurrent abnormality in chronic myeloid leukaemia blast crisis
TL;DR: Nine cases of Philadelphia (Ph)‐positive chronic myeloid leukaemia (CML) in which deletions of chromosome 20 were also detected by conventional karyotyping are presented, representing a new recurrent abnormality in CML blast crisis.