I
Irene Roberts
Researcher at University of Oxford
Publications - 229
Citations - 14626
Irene Roberts is an academic researcher from University of Oxford. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 58, co-authored 218 publications receiving 12818 citations. Previous affiliations of Irene Roberts include Imperial College Healthcare & St Mary's Hospital.
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Journal ArticleDOI
Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
Cesare Campagnoli,Irene Roberts,Sailesh Kumar,Phillip R. Bennett,Ilaria Bellantuono,Nicholas M. Fisk +5 more
TL;DR: Fetal blood MSCs similar to those derived from adult bone marrow, fetal liver, and fetal bone marrow circulate in first-trimester human blood and may provide novel targets for in utero cellular and gene therapy.
Journal ArticleDOI
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
Frédéric Rieux-Laucat,F. Le Deist,C Hivroz,Irene Roberts,Klaus-Michael Debatin,Alain Fischer,J P de Villartay +6 more
TL;DR: Fas expression and function were analyzed in three children (including two siblings) with a lymphoproliferative syndrome, two of whom also had autoimmune disorders as discussed by the authors, showing that a large deletion in the gene encoding Fas and no detectable cell surface expression characterized the most affected patient.
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Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report
Mark C. Walters,Rainer Storb,Melinda Patience,Wendy M. Leisenring,Terri Taylor,Jean E. Sanders,George E. Buchanan,Zora R. Rogers,Patricia A. Dinndorf,Sally C. Davies,Irene Roberts,Rosarita Dickerhoff,Andrew M. Yeager,Hsu Lewis,Joanne Kurtzberg,Kwaku Ohene-Frempong,Nancy Bunin,Françoise Bernaudin,Wing Yen Wong,J. Paul Scott,David A. Margolis,Elliott Vichinsky,Donna A. Wall,Allen S. Wayne,Charles H. Pegelow,Rupa Redding-Lallinger,Joseph Wiley,Martin R. Klemperer,William C. Mentzer,Franklin O. Smith,Keith M. Sullivan +30 more
TL;DR: Data confirm that allogenic bone marrow transplantation establishes normal erythropoiesis and is associated with improved growth and stable CNS imaging and pulmonary function in most patients.
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Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.
Journal ArticleDOI
The role of mesenchymal stem cells in haemopoiesis.
TL;DR: The multipotent capacity of MSC, their role in supporting haemopoiesis, and their immunoregulatory activity make MSC particularly attractive for therapeutic exploitation.