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Showing papers by "Soma Das published in 1997"

Journal Article•DOI•
Methylation-specific PCR simplifies imprinting analysis.

[...]

Takeo Kubota1, Soma Das1, Susan L. Christian1, Stephen B. Baylin2, James G. Herman2, David H. Ledbetter1 •
University of Chicago1, Johns Hopkins University2
01 May 1997-Nature Genetics

274 citations

Journal Article•DOI•
Methylation Analysis of the Fragile X Syndrome by PCR

[...]

Soma Das1, T. Kubota, M. Song, Roy Thomas Daniel, Elizabeth Berry-Kravis, T.W. Prior, B. Popovich, L. Rosser, T. Arinami, David H. Ledbetter •
University of Chicago1
01 Jan 1997-Genetic Testing
TL;DR: A PCR-based method for the analysis of methylation of the FMR1 gene, which involves bisulfite treatment of DNA prior to amplification, appears to be a rapid and reliable tool for the diagnosis of fragile X males.
Abstract: The fragile X syndrome is predominantly caused by a large expansion of a CGG trinucleotide repeat in the promoter region of the FMR1 gene, which is associated with methylation and downregu...

46 citations