One way that artists create compelling character animations is by manipulating details of a character's motion. This process is expensive and repetitive. We show that we can make such motion editing more efficient by generalizing the edits an animator makes on short sequences of motion to other sequences. Our method predicts frames for the motion using Gaussian process models of kinematics and dynamics. These estimates are combined with probabilistic inference. Our method can be used to propagate edits from examples to an entire sequence for an existing character, and it can also be used to map a motion from a control character to a very different target character. The technique shows good generalization. For example, we show that an estimator, learned from a few seconds of edited example animation using our methods, generalizes well enough to edit minutes of character animation in a high-quality fashion. Learning is interactive: An animator who wants to improve the output can provide small, correcting examples and the system will produce improved estimates of motion. We make this interactive learning process efficient and natural with a fast, full-body IK system with novel features. Finally, we present data from interviews with professional character animators that indicate that generalizing and propagating animator edits can save artists significant time and work.

Generalizing motion edits with Gaussian processes

BCLC strategy for prognosis prediction and treatment recommendation Barcelona Clinic Liver Cancer (BCLC) staging system. The 2022 update.

http://www.journal-of-hepatology.eu/article/S0168827821022236/pdf

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Background More than 20,000 candidates for kidney transplantation in the United States are sensitized to HLA and may have a prolonged wait for a transplant, with a reduced transplantation rate and an increased rate of death. One solution is to perform live-donor renal transplantation after the depletion of donor-specific anti-HLA antibodies. Whether such antibody depletion results in a survival benefit as compared with waiting for an HLA-compatible kidney is unknown. Methods We used a protocol that included plasmapheresis and the administration of low-dose intravenous immune globulin to desensitize 211 HLA-sensitized patients who subsequently underwent renal transplantation (treatment group). We compared rates of death between the group undergoing desensitization treatment and two carefully matched control groups of patients on a waiting list for kidney transplantation who continued to undergo dialysis (dialysis-only group) or who underwent either dialysis or HLA-compatible transplantation (dialysis-or-tr...

https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012376

Desensitization in HLA-incompatible kidney recipients and survival.

It is well known that there are significant racial disparities in health care outcomes, including surgery. However, the mechanisms that lead to these disparities are still not fully understood. In this comprehensive review of the currently published surgical disparity literature in the United States, we assess racial disparities in outcomes after surgical procedures, focusing on patient, provider, and systemic factors. The PubMed, EMBASE, and Cochrane Library electronic databases were searched with the keywords: healthcare disparities AND surgery AND outcome AND US. Only primary research articles published between April 1990 and December 2011 were included in the study. Studies analyzing surgical patients of all ages and assessing the endpoints of mortality, morbidity, or the likelihood of receiving surgical therapy were included. A total of 88 articles met the inclusion criteria. This evidence-based review was compiled in a systematic manner, relying on retrospective, cross-sectional, case-control, and prospective studies in the absence of Class I studies. The review found that patient factors such as insurance status and socioeconomic status (SES) need to be further explored, as studies indicated only a premature understanding of the relationship between racial disparities and SES. Provider factors such as differences in surgery rates and treatment by low volume or low quality surgeons also appear to play a role in minority outcome disparities. Finally, systemic factors such as access to care, hospital volume, and hospital patient population have been shown to contribute to disparities, with research consistently demonstrating that equal access to care mitigates outcome disparities.

https://www.journalacs.org/article/S1072-7515(12)01379-8/pdf

Racial disparities in surgical care and outcomes in the United States: a comprehensive review of patient, provider, and systemic factors.

Domino paired kidney donation : a strategy to make best use of live non-directed donation. Commentary

Coordinated navigation to a single perfectly known target by multiple cooperating sensor-equipped agents in a partially known static environment is investigated Original results on the spatial distribution of the agents under an-optimal policy are derived using dynamic programming and neurodynamic programming techniques Practical implications are discussed

Spatial distribution results for efficient multi-agent navigation

/pdf/deceased-donor-liver-size-and-the-sex-based-disparity-in-4r5jqchx0e.pdf

Deceased-donor liver size and the sex-based disparity in liver transplantation

Heterogeneous Circles for Liver Allocation.

Living donor kidney exchange, also referred to as kidney paired donation (KPD), is a relatively new transplant modality that is growing by leaps and bounds in the U.S. From its first realization as an exchange of kidneys between two incompatible donor/recipient pairs, KPD has expanded to include compatible pairs, nondirected donors, three-way and larger exchanges, and living/deceased donor exchanges. Innovations both clinical (transporting organs instead of donors, and improved HLA screening) and mathematical (simulation to test policies, optimization to find better and more matches) have made this modality even more useful and accessible. There are several independent multi-center paired donation registries and many more single-center registries operating in the U.S., but incompatible pairs are most likely to match when they participate in the largest possible paired exchange pool; a single, unified KPD program in the United States would likely best serve patients in search of matches.

Sommer E. Gentry

Papers

Domino paired kidney donation : a strategy to make best use of live non-directed donation. Commentary

Spatial distribution results for efficient multi-agent navigation

Deceased-donor liver size and the sex-based disparity in liver transplantation

Heterogeneous Circles for Liver Allocation.

Living donor kidney exchange.