S
Song-Guang Ren
Researcher at Cedars-Sinai Medical Center
Publications - 33
Citations - 1891
Song-Guang Ren is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Somatostatin & Acromegaly. The author has an hindex of 23, co-authored 33 publications receiving 1786 citations. Previous affiliations of Song-Guang Ren include University of California, Los Angeles.
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Journal ArticleDOI
EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas
Hidenori Fukuoka,Odelia Cooper,Anat Ben-Shlomo,Adam N. Mamelak,Song-Guang Ren,Dave Bruyette,Shlomo Melmed +6 more
TL;DR: Results indicate that inhibiting EGFR signaling may be a novel strategy for treating Cushing disease and preferentially targeted EGFR to mouse corticotroph cell nuclei, which resulted in higher Pomc expression and ACTH secretion, both of which were inhibited by gefitinib.
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Central and peripheral actions of somatostatin on the growth hormone–IGF-I axis
TL;DR: It is demonstrated that SRIF acts both centrally and peripherally to control the GH-IGF-I axis, providing a mechanistic explanation for SRIF analog action in treating patients with GH-secreting pituitary adenomas.
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Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface.
TL;DR: Results show that mLIF is a novel LPS-inducible proinflammatory neuroendocrine cytokine and the alternatively spliced diffusible LIF may play a paracrine role in activating pituitary ACTH secretion in synergy with hypothalamic CRH, implying a mechanism for central nervous system cytokine responses to immune signals.
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Pituitary-Directed Leukemia Inhibitory Factor Transgene Causes Cushing’s Syndrome: Neuro-Immune-Endocrine Modulation of Pituitary Development
TL;DR: Leukemia inhibitory factor (LIF) regulates the mature hypothalamic-pituitary-adrenal axis in vivo as mentioned in this paper and has been shown to play a key role in the terminal differentiation events of pituitary development.
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Early Multipotential Pituitary Focal Hyperplasia in the α-Subunit of Glycoprotein Hormone-Driven Pituitary Tumor-Transforming Gene Transgenic Mice
Rula A. Abbud,Ichiro Takumi,Erin M Barker,Song-Guang Ren,Dar-Yong Chen,Kolja Wawrowsky,Shlomo Melmed +6 more
TL;DR: Evidence is provided for early pituitary plasticity, whereby PTTG overexpression results in a phenotype switch in early pituitsary stem cells and promotes differentiated polyhormonal cell focal expansion.