S
Sonia Vizcaino
Researcher at University of Extremadura
Publications - 4
Citations - 240
Sonia Vizcaino is an academic researcher from University of Extremadura. The author has contributed to research in topics: Excretion & Genotype. The author has an hindex of 4, co-authored 4 publications receiving 232 citations.
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Journal ArticleDOI
Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.
Juan Antonio Carrillo,Angustias G. Herraiz,Sara I. Ramos,Guillermo Gervasini,Sonia Vizcaino,Julio Benítez +5 more
TL;DR: Smoking-induced increased CYP1A2 activity significantly diminished plasma olanzapine concentrations and the antipsychotic effect of the drug, and such inhibition can contribute to adverse drug interactions.
Journal ArticleDOI
Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and Other Caucasian populations.
TL;DR: Findings suggest that dose requirements for drugs metabolized by CYP3A and certain allele-disease association studies in white populations could show discrepancies in Spaniards, as well as the existence of 2 unusual subgroups: patients who were homozygous wild-type for both polymorphisms, and patients showing a CYP1-CYP3A4-3A5 genotype combination.
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The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 C3435T polymorphisms and gender on the urinary excretion of the metabolites of the H1-receptor antihistamine ebastine: a pilot study
TL;DR: Gender and the presence of the MDR1(C3435T) polymorphism both influence the excretion of ebastine metabolites in urine.
Journal ArticleDOI
Applicability of an Assay for Routine Monitoring of Highly Variable Concentrations of Olanzapine Based on HPLC with Mass Spectrometric Detection
TL;DR: The goal of this work was to develop a rapid and technically simple assay based on LC coupled with electrospray MS that would be capable of routinely determining extremely low OLZ concentrations, which could be very useful for monitoring schizophrenic patients who are heavy smokers.