Journal ArticleDOI
Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.
Juan Antonio Carrillo,Angustias G. Herraiz,Sara I. Ramos,Guillermo Gervasini,Sonia Vizcaino,Julio Benítez +5 more
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TLDR
Smoking-induced increased CYP1A2 activity significantly diminished plasma olanzapine concentrations and the antipsychotic effect of the drug, and such inhibition can contribute to adverse drug interactions.Abstract:
:This study investigated whether the smokinginducible cytochrome P450 (CYP) 1A2 and the polymorphic CYP2D6 play significant roles in the metabolism of olanzapine and its clinical effects at steady-state treatment. Caffeine and debrisoquine were used as measures of CYP1A2 and CYP2D6, respectiread more
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Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
TL;DR: There is a considerable variability in the CYP2D6 allele distribution among different ethnic groups, resulting in variable percentages of PMs, IMs, EMs and UMs in a given population and the number of alleles is still growing.
Journal ArticleDOI
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
Julia Kirchheiner,K. Nickchen,Michael Bauer,Ma-Li Wong,Julio Licinio,Ivar Roots,Jürgen Brockmöller +6 more
TL;DR: Combinations of polymorphisms in pharmacokinetic and pharmacodynamic pathways of relevance might contribute to identify genotypes associated with best and worst responders and they may also identify susceptibility to adverse drug reactions.
Journal ArticleDOI
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Sharon J. Gardiner,Evan J. Begg +1 more
TL;DR: The current evidence base for pharmacogenetics in relation to drug-metabolizing enzymes is summarized and no other drugs have an evidence base that is sufficient to justify prospective testing at present, although some warrant further evaluation.
Journal ArticleDOI
Drug interactions with smoking
TL;DR: In this paper, the mechanisms for drug interaction with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed and the most clinically significant interaction occurs with combined hormonal contraceptives and inhaled corticosteroids.
Journal ArticleDOI
Metabolic drug interactions with newer antipsychotics: a comparative review.
Edoardo Spina,Jose de Leon +1 more
TL;DR: Differences in the interaction potential among the novel antipsychotics currently available may be predicted based on their metabolic pathways, and the clinical relevance of these interactions should be interpreted in relation to the relative width of their therapeutic index.
References
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Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
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The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients
Journal ArticleDOI
Polymorphic hydroxylation of debrisoquine in man
TL;DR: Family studies supported the view that alicyclic 4-hydroxylation of debrisoquine is controlled by a single autosomal gene and that a defect in this metabolic step is caused by a recessive allele.
Journal ArticleDOI
P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.
TL;DR: P450 induction by xenobiotics may in some cases lead to a perturbation of endogenous regulatory circuits with associated pathophysiological consequences, leading to the proposal that these receptors may primarily serve to modulate hepatic P450 activity in response to endogenous dietary or hormonal stimuli.