S
Sonia Zuñiga
Researcher at Spanish National Research Council
Publications - 49
Citations - 3059
Sonia Zuñiga is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Coronavirus & Gene. The author has an hindex of 22, co-authored 41 publications receiving 2437 citations. Previous affiliations of Sonia Zuñiga include Autonomous University of Madrid.
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Journal ArticleDOI
Continuous and Discontinuous RNA Synthesis in Coronaviruses
TL;DR: Coronaviruses encode proofreading machinery, unique in the RNA virus world, to ensure the maintenance of their large genome size.
Journal ArticleDOI
Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate
Fernando Almazán,Marta L. DeDiego,Isabel Sola,Sonia Zuñiga,Jose L. Nieto-Torres,Silvia Márquez-Jurado,Germán Andrés,Luis Enjuanes +7 more
TL;DR: The construction of a full-length infectious cDNA clone of the MERS-CoV genome in a bacterial artificial chromosome is reported here, providing a reverse genetics system to study the molecular biology of the virus and to develop attenuated viruses as vaccine candidates.
Journal ArticleDOI
Sequence Motifs Involved in the Regulation of Discontinuous Coronavirus Subgenomic RNA Synthesis
TL;DR: The canonical CS-B was nonessential for the generation of subgenomic mRNAs (sgmRNAs), but its presence led to transcription levels at least 103-fold higher than those in its absence.
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Biochemical Aspects of Coronavirus Replication and Virus-Host Interaction
TL;DR: Both viral and cellular proteins are required for replication and transcription, and the role of selected proteins is addressed.
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Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.
Fernando Almazán,Marta L. DeDiego,Carmen Galán,David Escors,Enrique Alvarez,Javier Ortego,Isabel Sola,Sonia Zuñiga,Sara Alonso,José L. Moreno,Aitor Nogales,Carmen Capiscol,Luis Enjuanes +12 more
TL;DR: The engineering of a full-length infectious cDNA clone and a functional replicon of the severe acute respiratory syndrome coronavirus (SARS-CoV) Urbani strain as bacterial artificial chromosomes (BACs) is described and it is shown that the recently described RNA-processing enzymes exoribonuclease, endorib onuclease and 2′-O-ribose methyltransferase were essential for efficient coronav virus RNA synthesis.