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Isabel Sola
Researcher at Spanish National Research Council
Publications - 90
Citations - 10714
Isabel Sola is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Coronavirus & Gene. The author has an hindex of 36, co-authored 76 publications receiving 7917 citations. Previous affiliations of Isabel Sola include University of Bristol & Autonomous University of Madrid.
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
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Continuous and Discontinuous RNA Synthesis in Coronaviruses
TL;DR: Coronaviruses encode proofreading machinery, unique in the RNA virus world, to ensure the maintenance of their large genome size.
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Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate
Fernando Almazán,Marta L. DeDiego,Isabel Sola,Sonia Zuñiga,Jose L. Nieto-Torres,Silvia Márquez-Jurado,Germán Andrés,Luis Enjuanes +7 more
TL;DR: The construction of a full-length infectious cDNA clone of the MERS-CoV genome in a bacterial artificial chromosome is reported here, providing a reverse genetics system to study the molecular biology of the virus and to develop attenuated viruses as vaccine candidates.
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Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis
Carlos Castaño-Rodríguez,José M. Honrubia,Javier Gutiérrez-Álvarez,Marta L. DeDiego,Jose L. Nieto-Torres,Jose M. Jimenez-Guardeño,Jose Angel Regla-Nava,Raúl Fernandez-Delgado,Carmina Verdiá-Báguena,María Queralt-Martín,Grazyna Kochan,Stanley Perlman,Vicente M. Aguilella,Isabel Sola,Luis Enjuanes +14 more
TL;DR: Key roles for the ion channel and PBM domains in optimal virus replication and pathogenesis are demonstrated and suggest that the viral viroporins and PBMs are suitable targets for antiviral therapy and for mutation in attenuated SARS-CoV vaccines.
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Sequence Motifs Involved in the Regulation of Discontinuous Coronavirus Subgenomic RNA Synthesis
TL;DR: The canonical CS-B was nonessential for the generation of subgenomic mRNAs (sgmRNAs), but its presence led to transcription levels at least 103-fold higher than those in its absence.