Sonja Steinhauer

TL;DR: This study demonstrates that molecular profiling of FFPE tumor samples improves prognostication of ACC beyond clinical/histopathological parameters and identifies new potential drug targets, paving the way to precision medicine in this rare disease.

TL;DR: GEM‐based chemotherapy is a well‐tolerated, but modestly active, regimen against advanced ACC and remains an important option for salvage treatment for advanced ACC.

TL;DR: High dose estradiol treatment prevented development of post-MI remodeling, as assessed by in vivo and in vitro parameters of LV dysfunction, suggesting that estrogen may hold the potential of becoming a new form of heart failure treatment.

TL;DR: CYP2W1 is highly expressed in both normal and neoplastic adrenal glands making it a promising tool for targeted therapy in ACC, and may represent a new predictive marker for the response to mitotane treatment.

TL;DR: In the isolated buffer-perfused rat heart, estradiol treatment caused improved functional recovery after ischemia/reperfusion injury, however, this improvement did not include preservation of high-energy phosphate metabolism.