S
Sönke Harder
Researcher at University of Hamburg
Publications - 32
Citations - 713
Sönke Harder is an academic researcher from University of Hamburg. The author has contributed to research in topics: Mucin & Biology. The author has an hindex of 13, co-authored 25 publications receiving 595 citations.
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Journal ArticleDOI
Functional Annotation of Two Orphan G-protein-coupled Receptors, Drostar1 and -2, from Drosophila melanogaster and Their Ligands by Reverse Pharmacology
Hans-Jürgen Kreienkamp,Hannes Jon Larusson,Ines Witte,Thomas Roeder,Necla Birgül,Hans-Hinrich Hönck,Sönke Harder,Günter Ellinghausen,Friedrich Buck,Dietmar Richter +9 more
TL;DR: Localization of receptor transcripts identifies a role of the new transmitter system in visual information processing as well as endocrine regulation and affects ligand binding, as previously described for somatostatin receptors.
Journal ArticleDOI
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients.
Kai Bartkowiak,Katharina E. Effenberger,Sönke Harder,Antje Andreas,Friedrich Buck,Jasna Peter-Katalinic,Klaus Pantel,Burkhard Brandt +7 more
TL;DR: The results suggest the presence of a previously not recognized stress resistant DTC population that combines stem/progenitor attributes with an UPR phenotype, and the potential of both proteins as novel markers for DTC detection.
Journal ArticleDOI
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.
Bianca T. Hofmann,Laura Schlüter,Philip Lange,Baris Mercanoglu,Florian Ewald,Aljonna Fölster,Aeint Steffen Picksak,Sönke Harder,Alexander T. El Gammal,Katharina Grupp,Cenap Güngör,Astrid Drenckhan,Hartmut Schlüter,Christoph Wagener,Jakob R. Izbicki,Manfred Jücker,Maximilian Bockhorn,Gerrit Wolters-Eisfeld +17 more
TL;DR: This study substantiates the influence of altered O-glycan (Tn/STn) expression on oncogenic properties in pancreatic cancer and identifies O-GalNAc modified Nucleolin as novel prognostic marker.
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Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/ progenitor cell protein profile.
Kai Bartkowiak,Marek Wieczorek,Friedrich Buck,Sönke Harder,Jennifer Moldenhauer,Katharina E. Effenberger,Klaus Pantel,Jasna Peter-Katalinic,Burkhard Brandt +8 more
TL;DR: DTC from breast cancer patients' bone marrow expressed cytokeratin 5, which further supports the hypothesis that the protein expression profile of DTC might be reminiscent of the expression profiles of the early tumor, which differs from the advanced tumor.
Journal ArticleDOI
Cloning of Two Thyrotropin-Releasing Hormone Receptor Subtypes from a Lower Vertebrate (Catostomus commersoni): Functional Expression, Gene Structure, and Evolution
Sönke Harder,Oliver Dammann,Friedrich Buck,Henk Zwiers,Karl Lederis,Dietmar Richter,Thomas O. Bruhn +6 more
TL;DR: The analysis of the gene structure of ccTRH-R and the amino acid sequence comparisons of mammalian and teleost TRH- R of both subtypes suggest that TRH receptors have been highly conserved during the course of vertebrate evolution.