S
Søren Thirup
Researcher at Aarhus University
Publications - 69
Citations - 5195
Søren Thirup is an academic researcher from Aarhus University. The author has contributed to research in topics: Ternary complex & EF-Tu. The author has an hindex of 27, co-authored 67 publications receiving 4878 citations. Previous affiliations of Søren Thirup include Lundbeck.
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Journal ArticleDOI
Crystal Structure of the Ternary Complex of Phe-tRNAPhe, EF-Tu, and a GTP Analog
Poul Nissen,Morten Kjeldgaard,Søren Thirup,Galina Polekhina,Ludmila Reshetnikova,Brian F.C. Clark,Jens Nyborg +6 more
TL;DR: The overall shape of the ternary complex is similar to that of the translocation factor, EF-G-GDP, and this suggests a novel mechanism involving “molecular mimicry” in the translational apparatus.
Journal ArticleDOI
Using known substructures in protein model building and crystallography
T.A. Jones,Søren Thirup +1 more
TL;DR: Retinol binding protein can be constructed from a small number of large substructures taken from three unrelated proteins, which requires the use of a skeleton representation for the electron density which improves the determination of the initial chain tracing.
Journal ArticleDOI
The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation.
TL;DR: GTP binding by EF-Tu leads to dramatic conformational changes which expose the tRNA binding site, which may affect the GTPase activity.
Journal ArticleDOI
Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.
TL;DR: Structural details of the guanosine diphosphate binding to a modified form of elongation factor Tu from Escherichia coli, resulting from X‐ray crystallographic studies, are reported.
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LysM domains mediate lipochitin–oligosaccharide recognition and Nfr genes extend the symbiotic host range
Simona Radutoiu,Lene H. Madsen,Esben Bjørn Madsen,Anna Jurkiewicz,Eigo Fukai,Esben M. Quistgaard,Anita S. Albrektsen,Euan K. James,Søren Thirup,Jens Stougaard +9 more
TL;DR: It is demonstrated that expression of Lotus japonicus Nfr1 and Nfr5 Nod‐factor receptor genes in Medicago truncatula and L. filicaulis extends their host range to include bacterial strains, Mesorhizobium loti or DZL, and that recognition depends on the structure of the lipochitin–oligosaccharide Nod•factor.