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Principles Of Fluorescence Spectroscopy

Endometriosis

The English-language dictionary defines wrinkles as "small furrows, ridges, or creases on a normally smooth surface, caused by crumpling, folding, or shrinking". In this paper we review the scientific aspects of wrinkling and the related phenomenon of buckling. Specifically, we discuss how and why wrinkles/buckles form in various materials. We also describe several examples from everyday life, which demonstrate that wrinkling or buckling is indeed a commonplace phenomenon that spans a multitude of length scales. We will emphasize that wrinkling is not always a frustrating feature (e.g., wrinkles in human skin), as it can help to assemble new structures, understand important physical phenomena, and even assist in characterizing chief material properties.

Soft matter with hard skin : From skin wrinkles to templating and material characterization

The COVID-19 pandemic: Impacts on cities and major lessons for urban planning, design, and management

Microfluidics is an emerging field that has given rise to a large number of scientific and technological developments over the last few years. This review reports on the use of various materials, such as silicon, glass and polymers, and their related technologies for the manufacturing of simple microchannels and complex systems. It also presents the main application fields concerned with the different technologies and the most significant results reported by academic and industrial teams. Finally, it demonstrates the advantage of developing approaches for associating polymer technologies for manufacturing of fluidic elements with integration of active or sensitive elements, particularly silicon devices.

https://iopscience.iop.org/article/10.1088/0960-1317/17/5/R01/pdf

Lab-on-chip technologies: making a microfluidic network and coupling it into a complete microsystem : a review

We report a highly accurate single-step label-free testing technology for simultaneous and independent hematocrit (Hct) and hemoglobin (Hb) level detection from a drop of whole blood by employing a disposable paper strip sensor interfaced with a portable impedimetric device. The paper strip is fabricated by in situ automated printing of a customized electrode template on the non-glossy side of a commercially available photo paper substrate followed by graphite deposition. The integrated platform device technology additionally includes a compact detection cum readout unit comprising a high precision impedance converter system that combines an on-board frequency generator with an analog-to-digital converter evaluation board, collectively interfaced with a central processor, calibration circuit, and smartphone. Employing a dispensed blood sample volume of 25 μL, the device is shown to have a sensitivity of 92 Ω/Hct and 287 Ω/Hb at an optimal frequency of 57 kHz. The respective linear response regimes appear to be wide enough to cover physiologically relevant limits, with excellent stability and reproducibility. Validation with clinical samples reveals limits of detection of Hct and Hb levels as low as 4.66% and 1.89 g dL-1, respectively, which are beyond the quantitative capability of commonly used affordable point of care test kits. The envisaged paradigm of rapid, robust, highly accurate, energy-efficient, simple, user-friendly, multiplex portable detection, obviating any possible ambiguities in interpretation due to common artefacts of colorimetric detection technologies such as optical interference with the image analytical procedure due to the inherent redness of blood samples and background illumination, renders this ideal for deployment in resource-limited settings.

Simultaneous quantitative detection of hematocrit and hemoglobin from whole blood using a multiplexed paper sensor with a smartphone interface.

The unconventional multi-sigmoidal kinetic behaviour of protein aggregation at a temperature gradient condition is reported in this study. To establish a feasible theory for protein aggregation kinetics at a temperature gradient condition, the spatial height of the protein solution is divided into hypothetical layers and the kinetic equations in those layers are solved. Furthermore, we endeavour to study numerically the effect of the temperature gradient on the kinetics of oligomer-mediated protein aggregation and protein inhibition.

Kinetics of protein aggregation at a temperature gradient condition.

system. The wrinkle patterns of the buckled film can cause malfunctioning or catastrophic failure of device fabricated on elastomeric base. If the underlying topology of the film modified, the stress on bi­ layer system does not remain equi-biaxial. Thus by engineering the surface topology of elastomeric substrate, the stress developed on the deposited thin film can be substantially reduced, for its meaningful applications. In the present work the planar topology of an elastomeric base (PDMS) was engineered into array of parallel ridges and it was verified with simulations and experiments that by varying the width of the ridges it is possible to control the stress magnitude below the critical value, thereby reducing the occurrence of wrinkles of the film surface over the ridge area.

http://ieeexplore.ieee.org/iel5/5724994/5735330/05735356.pdf

PDMS elastomer by engineering the substrate topology

Reactive astrogliosis is a common pathological hallmark of central nervous system (CNS) injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly understood. Here, we report that conditional deletion of serum response factor (SRF) in adult astrocytes causes reactive-like hypertrophic astrocytes throughout the mouse brain. These SrfGFAP-ERCKO astrocytes do not affect neuron survival, synapse numbers, synaptic plasticity or learning and memory. However, the brains of Srf knockout mice exhibited neuroprotection against kainic-acid induced excitotoxic cell death. Relevant to human neurodegenerative diseases, SrfGFAP-ERCKO astrocytes abrogate nigral dopaminergic neuron death and reduce β-amyloid plaques in mouse models of Parkinson’s and Alzheimer’s disease, respectively. Taken together, these findings establish SRF as a key molecular switch for the generation of reactive astrocytes with neuroprotective functions that attenuate neuronal injury in the setting of neurodegenerative diseases.

/pdf/srf-deficient-astrocytes-provide-neuroprotection-in-mouse-3neaol70.pdf

Soumen Das

Papers

Simultaneous quantitative detection of hematocrit and hemoglobin from whole blood using a multiplexed paper sensor with a smartphone interface.

Kinetics of protein aggregation at a temperature gradient condition.

PDMS elastomer by engineering the substrate topology

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

P6: Sodium Bicarbonate Alters Blood Coagulability and Enhances Heparin Effect in a Simulated Impella Purge Gap Model