MEDICAL LITERATURE has been deluged during the past few years with books and papers on penicillin; but a book which has been produced under the general editorship of Sir Alexander Fleming himself represents a complete and authoritative summary of penicillin therapy as it stands today.' The book contains a series of independent contributions by \"experienced and eminent men who have worked with penicillin in Great Britain\". Their opinions and practical methods differ slightly, and there is some overlapping; but these are not disadvantageous, comparison and contrast lending interest to the reading. In the first or general section of the book Fleming contributes two chapters, one on the history and development of penicillin, introducing some interesting sidelights in the romance of discovery, the other on the bacteriological control of penicillin therapy. In both chapters the information is set out in meticulous detail and with a clarity and simplicity which can be enjoyed by all readers. Fleming also gives the right perspective to the place of penicillin amongst the antibiotics and lays down the principles of treatment. Both chapters are well illustrated and are the most outstanding in the book. Included in this first section also are chapters on the chemistry and manufacture of penicillin and its pharmacy, pharmacology and methods of administration. The second section of the book is entirely clinical, giving each author's view on the use of penicillin therapy in a disease or an infection of some particular region of the body. The entire range of peniCillin-sensitive conditions is considered in twenty authoritative and clearly written chapters; these contain many references and illustrations. Dental and veterinary diseases are also given fairly full consideration. The final section is a condensed resume of much of the preceding chapters and is written for. the general practttioner. This chapter is superttuous: it does not contain enough detall to be of much practical value. The book as a Whole, however, will undoubtedly be considered a classical contribution to medical literature and is strongly recommended, not only because of the general interest of its topic, but as a reference book on penicillin therapy of hitherto unequalled excellence. The typography, although conforming to war economy standards, is clear and the paper is good. There is an excellent list of references and the index is satisfactory.

Gray's Anatomy

SummaryThis article describes the use of the Hall Effect strain transducer (HEST) in a new arthroscopic technique to study the normal anterior cruciate ligament (ACL) in-vivo. Study participants were patient volunteers with normal ACLs undergoing diagnostic arthroscopic or meniscal surgery under local anaesthesia. The HEST was implanted into the Anterior Medial Band (AMB) of the ACL. Anterior shear loading of the tibia in relation to the fixed femur at 30° of knee flexion (Lachman test), produced significantly greater strain values in comparison to anterior shear loading at 90° (Anterior Drawer test). During isometric quadriceps contraction a significant increase in AMB strain was measured with the knee flexed to 30°, while no significant change was measured at 90°. For quadriceps contraction there were significantly higher values of AMB strain measured at 30° of knee flexion in comparison to that observed at 90°. For active range of motion (AROM) the AMB was strained between 10° and 48°, and unstrained between 48° and 110°. During passive range of motion (PROM) the AMB remained unstrained until the joint was brought into extension. There were significant differences in strain values found between AROM and PROM at the flexion angles 10°, 20°, 30° and 40°, while between 50° and 110° there were no significant differences. These results confirm previous studies that the Lachman test is a superior technique in comparison to the classic anterior drawer test for evaluating the AMB. They suggest that isometric quadriceps activity at 90° of knee flexion can be prescribed for rehabilitation immediately after ACL reconstruction. These data indicate that AROM (between the limits of 50° and 110°) and PROM may also be performed with minimal risk of strain to a reconstructive replacement. The PROM data may also serve as an important standard for the reconstruction of the ACL.RésuméCet article décrit l'utilisation du transducteur de tension par effet Hall (TTEH) dans une nouvelle technique arthroscopique pour étudier le ligament croisé antérieur (LCA) normal in vivo. Les participants à l'étude étaient des patients volontaires avec LCA normal, soumis à une arthroscopie à visée diagnostique ou à une intervention sur un ménisque, sous anesthésie locale. Le TTEH fut implanté dans la bande médiane antérieure (BMA) du LCA. La translation antérieure du tibia, le fémur étant fixé et le genou fléchi à 30° (test de Lachman), donne des chiffres de tension sensiblement plus élevés par rapport à ceux obtenus en flexion à 90° (épreuve de tiroir antérieur). Lors de la contraction isométrique du quadriceps, une augmentation significative de la tension de la BMA a été notée, le genou fléchi à 30°, alors qu'aucune modification n'était mesurable à 90°. Lors des contractions du quadriceps, les chiffres de tension de la BMA, le genou fléchi à 30° étaient notablement supérieurs à ceux enregistrés à 90°. Dans le secteur de mobilité active, la BMA était sous tension entre 10° et 48° et ne l'était pas de 48° à 110°. Durant la mobilisation passive la BMA restait détendue jusqu'à ce que l'articulation soit mise en extension complète. On a trouvé des différences significatives entre les tensions mesurées lors des mobilisations actives et passives aux angles de flexion de 10°, 20°, 30° et 40°, alors qu'il n'y en avait pas de 50° à 110°. Ces résultats confirment les études antérieures selon lesquelles le test de Lachman est une technique d'examen plus sensible que la classique recherche du tiroir antérieur pour évaluer la BMA. Ces résultats laissent à penser que l'activité isométrique du quadriceps, le genou fléchi à 90°, peut être prescrite pour la réeducation, immédiatement après reconstruction du LCA. Ces données indiquent également que la mobilisation active (entre 50° et 110°) et la mobilisation passive peuvent être effectuées avec des risques mineurs après reconstruction. Les données concernant la mobilité passive peuvent aussi fournir des repères valables pour la reconstruction du LLA.

The measurement of anterior cruciate ligament stain in vivo

Die Versorgung schwerstverletzter Patienten im Schockraum bedeutet fur das multidisziplinare Behandlungsteam einen strukturierten Evaluationsprozess in einen zielgerichteten Behandlungsprozess zu uberfuhren. Neben dem Faktor Zeit und dem Erkennen vital bedrohlicher Verletzungen, die haufig unter dem Begriff „deadly six“ zusammengefasst werden, sollten aber auch sog. „Bagatellverletzungen“ nicht ubersehen werden, da sie die Lebensqualitat nach Trauma mitunter entscheidend beeinflussen konnen. Die S3-Leitlinie Polytrauma erhebt nicht den Anspruch auf Vollstandigkeit. Wichtige Inhalte, wie z. B. die Versorgung von Kindern sind bisher noch nicht in die Leitlinie eingeflossen, werden aber fur die Uberarbeitung fest eingeplant.

S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung

Purpose To evaluate the effectiveness of all-inside repair of posterior lateral meniscus root full-thickness tears with preoperative and postoperative magnetic resonance imaging (MRI) and to propose a system of classifying posterior lateral meniscus root tears. Methods From June 2003 to March 2007, 27 (6.95%) of a consecutive series of 388 anterior cruciate ligament reconstructions had a concomitant posterior lateral meniscus root tear. Of the patients, 25 (92.6%) were followed up for a more than 1 year. There were 22 male and 3 female patients, with a mean age of 28.8 years. The mean timing of surgery after injury was 40.8 months. The preoperative and postoperative MRI scans were analyzed and compared. We classified posterior lateral meniscus root tears according to arthroscopic findings. Results There was no postoperative effusion, joint-line tenderness, or positive McMurray provocation testing observed at the last follow-up. No statistically significant improvement was observed in the coronal plane in the 18 follow-up MRI scans ( P = .096); however, sagittal extrusion improved significantly ( P = .007). Posterior lateral meniscus root tears were classified based on arthroscopic findings: type I, oblique flap; type II, T shape; type III, longitudinal cleavage; or type IV, chronic inner loss. A type I tear was found in 7 patients, type II in 4, type III in 4, and type IV in 10. Conclusions After repair of posterior lateral meniscus root tears, MRI showed that the displaced lateral meniscus was reduced, mainly in the sagittal plane. Posterior lateral meniscus root tears were classified based on arthroscopic findings: type I, oblique flap; type II, T shape; type III, longitudinal cleavage; or type IV, chronic inner loss. Level of Evidence Level IV, therapeutic case series.

Results of Arthroscopic All-Inside Repair for Lateral Meniscus Root Tear in Patients Undergoing Concomitant Anterior Cruciate Ligament Reconstruction

Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics—A 3D finite element analysis

Many experimental testing techniques have been adopted in order to provide an understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this review article is to amalgamate results from these studies to provide readers with an overview of the studies conducted and their contribution to our current understanding of the biomechanics and function of the IVD. The overview is presented in a way that should prove useful to experimentalists and computational modellers. Mechanical properties of whole IVDs can be assessed conveniently by testing ‘motion segments’ comprising two vertebrae and the intervening IVD and ligaments. Neural arches should be removed if load-sharing between them and the disc is of no interest, and specimens containing more than two vertebrae are required to study ‘adjacent level’ effects. Mechanisms of injury (including endplate fracture and disc herniation) have been studied by applying complex loading at physiologically-relevant loading rates, whereas mechanical evaluations of surgical prostheses require slower application of standardised loading protocols. Results can be strongly influenced by the testing environment, preconditioning, loading rate, specimen age and degeneration, and spinal level. Component tissues of the disc (anulus fibrosus, nucleus pulposus, and cartilage endplates) have been studied to determine their material properties, but only the anulus has been thoroughly evaluated. Animal discs can be used as a model of human discs where uniform non-degenerate specimens are required, although differences in scale, age, and anatomy can lead to problems in interpretation.

https://research-information.bris.ac.uk/files/106096608/1_s2.0_S1751616117300449_main.pdf

Biomechanics of the human intervertebral disc: a review of testing techniques and results

The menisci of the knee act primarily to redistribute contact force across the tibio-femoral articulation. This meniscal function is achieved through a combination of the material, geometry and attachments of the menisci. The main ligaments that attach the menisci to the tibia (insertional ligaments, deep medial collateral ligament), the femur (meniscofemoral ligaments, deep medial collateral ligament) and each other (the anterior intermeniscal ligament) are the means by which the contact force between tibia and femur is distributed into hoop stresses in the menisci to reduce contact pressure at the joint. This means that the functional biomechanics of the menisci cannot be considered in isolation and should be considered as the functional biomechanics of the meniscus-meniscal ligament construct. This article presents the current knowledge on the anatomy and functional biomechanics of the meniscus and its associated ligaments. Much is known about the function of the meniscus-meniscal ligament construct; however, there still remain significant gaps in the literature in terms of the properties of the anterior intermeniscal ligament and its function, the properties of the insertional ligaments, and the most appropriate ways to reconstruct meniscal function surgically.

Biomechanics of the meniscus-meniscal ligament construct of the knee.

Biomechanics of the human intervertebral disc: A review of testing techniques and results

Improved protective measures and medical care has increased the survivability from battlefield injuries. In an attempt to reduce the debilitating consequences of blast injury, understanding and mitigating the effects of explosion on the extremities is key. In this study, forensic biomechanical analyses have been applied to determine mechanisms of injury after the traumatic event. The aims of this study were (i) to determine which effects of the explosion are responsible for combat casualty extremity bone injury in two distinct environments, namely open, free-field (open group), and in vehicle or in cover (enclosed group), and (ii) to determine whether patterns of combat casualty bone injury differed between environments. Medical records of casualties admitted to a military hospital in Afghanistan were reviewed over a six-month period. Explosive injuries have been sub-divided traditionally into primary, secondary and tertiary effects. All radiographs were independently reviewed by a military radiologist, a team of military orthopaedic surgeons and a team of academic biomechanists, in order to determine 'zones of injury' (ZoIs), and their related mechanisms. Sixty-two combat casualties with 115 ZoIs were identified. Thirty-four casualties in the open group sustained 56 ZoIs; 28 casualties in the enclosed group sustained 59 ZoIs. There was no statistical difference in mean ZoIs per casualty between groups (p = 0.54). There was a higher proportion of lower limb injuries in the enclosed group compared with the open group (p < 0.05). Of the casualties in the open group, 1 ZoI was owing to the primary effects of blast, 10 owing to a combination of primary and secondary blast effects, 23 owing to secondary blast effects and 24 owing to tertiary blast effects. In contrast, tertiary blast effects predominated in the enclosed group, accounting for 96 per cent of ZoIs. These data clearly demonstrate two distinct injury groups based upon the casualties' environment. The enclosed environment appears to attenuate the primary and secondary effects of the explosion. However, tertiary blast effects were the predominant mechanism of injury, with severe axial loading to the lower extremity being a characteristic of the fractures seen. The development of future mitigation strategies must focus on reducing all explosion-related injury mechanisms. Integral to this process is an urgent requirement to better understand the behaviour of bone in this unique environment.

Blast-related fracture patterns: a forensic biomechanical approach.

The aim of this study was to assess the accuracy of placement of pelvic binders and to determine whether circumferential compression at the level of the greater trochanters is the best method of reducing a symphyseal diastasis. Patients were identified by a retrospective review of all pelvic radiographs performed at a military hospital over a period of 30 months. We analysed any pelvic radiograph on which the buckle of the pelvic binder was clearly visible. The patients were divided into groups according to the position of the buckle in relation to the greater trochanters: high, trochanteric or low. Reduction of the symphyseal diastasis was measured in a subgroup of patients with an open-book fracture, which consisted of an injury to the symphysis and disruption of the posterior pelvic arch (AO/OTA 61-B/C). We identified 172 radiographs with a visible pelvic binder. Five cases were excluded due to inadequate radiographs. In 83 (50%) the binder was positioned at the level of the greater trochanters. A high position was the most common site of inaccurate placement, occurring in 65 (39%). Seventeen patients were identified as a subgroup to assess the effect of the position of the binder on reduction of the diastasis. The mean gap was 2.8 times greater (mean difference 22 mm) in the high group compared with the trochanteric group (p < 0.01). Application of a pelvic binder above the level of the greater trochanters is common and is an inadequate method of reducing pelvic fractures and is likely to delay cardiovascular recovery in these seriously injured patients.

Spyros D. Masouros

Papers

Biomechanics of the human intervertebral disc: a review of testing techniques and results

Biomechanics of the meniscus-meniscal ligament construct of the knee.

Biomechanics of the human intervertebral disc: A review of testing techniques and results

Blast-related fracture patterns: a forensic biomechanical approach.

Accurate placement of a pelvic binder improves reduction of unstable fractures of the pelvic ring