抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Noisy Intermediate-Scale Quantum (NISQ) technology will be available in the near future. Quantum computers with 50-100 qubits may be able to perform tasks which surpass the capabilities of today's classical digital computers, but noise in quantum gates will limit the size of quantum circuits that can be executed reliably. NISQ devices will be useful tools for exploring many-body quantum physics, and may have other useful applications, but the 100-qubit quantum computer will not change the world right away --- we should regard it as a significant step toward the more powerful quantum technologies of the future. Quantum technologists should continue to strive for more accurate quantum gates and, eventually, fully fault-tolerant quantum computing.

/pdf/quantum-computing-in-the-nisq-era-and-beyond-4jnwt61yqa.pdf

Quantum Computing in the NISQ era and beyond

Noisy Intermediate-Scale Quantum (NISQ) technology will be available in the
near future. Quantum computers with 50-100 qubits may be able to perform tasks
which surpass the capabilities of today's classical digital computers, but
noise in quantum gates will limit the size of quantum circuits that can be
executed reliably. NISQ devices will be useful tools for exploring many-body
quantum physics, and may have other useful applications, but the 100-qubit
quantum computer will not change the world right away --- we should regard it
as a significant step toward the more powerful quantum technologies of the
future. Quantum technologists should continue to strive for more accurate
quantum gates and, eventually, fully fault-tolerant quantum computing.

/pdf/quantum-computing-in-the-nisq-era-and-beyond-3utyn832f7.pdf

The internet-a vast network that enables simultaneous long-range classical communication-has had a revolutionary impact on our world. The vision of a quantum internet is to fundamentally enhance internet technology by enabling quantum communication between any two points on Earth. Such a quantum internet may operate in parallel to the internet that we have today and connect quantum processors in order to achieve capabilities that are provably impossible by using only classical means. Here, we propose stages of development toward a full-blown quantum internet and highlight experimental and theoretical progress needed to attain them.

/pdf/quantum-internet-a-vision-for-the-road-ahead-5g5cy9s9m0.pdf

Quantum internet: A vision for the road ahead

Microwave photonics with superconducting quantum circuits

Despite the tremendous progress of quantum cryptography, efficient quantum communication over long distances (≥ 1000 km) remains an outstanding challenge due to fiber attenuation and operation errors accumulated over the entire communication distance. Quantum repeaters (QRs), as a promising approach, can overcome both photon loss and operation errors, and hence significantly speedup the communication rate. Depending on the methods used to correct loss and operation errors, all the proposed QR schemes can be classified into three categories (generations). Here we present the first systematic comparison of three generations of quantum repeaters by evaluating the cost of both temporal and physical resources, and identify the optimized quantum repeater architecture for a given set of experimental parameters for use in quantum key distribution. Our work provides a roadmap for the experimental realizations of highly efficient quantum networks over transcontinental distances.

/pdf/optimal-architectures-for-long-distance-quantum-4e9ajfn1nd.pdf

Optimal architectures for long distance quantum communication

Quantum repeaters (QRs) provide a way of enabling long distance quantum communication by establishing entangled qubits between remote locations. In this Letter, we investigate a new approach to QRs in which quantum information can be faithfully transmitted via a noisy channel without the use of long distance teleportation, thus eliminating the need to establish remote entangled links. Our approach makes use of small encoding blocks to fault-tolerantly correct both operational and photon loss errors. We describe a way to optimize the resource requirement for these QRs with the aim of the generation of a secure key. Numerical calculations indicate that the number of quantum memory bits at each repeater station required for the generation of one secure key has favorable polylogarithmic scaling with the distance across which the communication is desired.

/pdf/ultrafast-and-fault-tolerant-quantum-communication-across-3fkvvay2s8.pdf

Ultrafast and Fault-Tolerant Quantum Communication across Long Distances

We investigate the usefulness of a recently introduced five qubit state by Brown $\it et al. \normalfont$ \cite{Brown} for quantum teleportation, quantum state sharing and superdense coding. It is shown that this five-qubit state can be utilized for perfect teleportation of arbitrary single and two qubit systems. We devise various schemes for quantum state sharing of an arbitrary single and two particle state via cooperative teleportation. We later show that this state can be used for superdense coding as well. It is found that five classical bits can be sent by sending only three quantum bits.

Perfect Teleportation, Quantum state sharing and Superdense Coding through a Genuinely Entangled Five-qubit State

We provide various schemes for the splitting up of quantum information into parts using four- and five-partite cluster states. Explicit protocols for the quantum information splitting (QIS) of single- and two-qubit states are illustrated. It is found that the four-partite cluster state can be used for QIS of an entangled state and the five-partite cluster state can be used for QIS of an arbitrary two-qubit state. The schemes considered here are also secure against certain eavesdropping attacks.

https://www.prl.res.in/~library/Panigrahi_PK_062333_78_08_abst.pdf

Quantum-information splitting using multipartite cluster states

Despite the tremendous progress of quantum cryptography, efficient quantum communication over long distances (>1000km) remains an outstanding challenge due to fiber attenuation and operation errors accumulated over the entire communication distance. Quantum repeaters, as a promising approach, can overcome both photon loss and operation errors, and hence significantly speedup the communication rate. Depending on the methods used to correct loss and operation errors, all the proposed QR schemes can be classified into three categories (generations). Here we present the first systematic comparison of three generations of quantum repeaters by evaluating the cost of both temporal and physical resources, and identify the optimized quantum repeater architecture for a given set of experimental parameters. Our work provides a roadmap for the experimental realizations of highly efficient quantum networks over transcontinental distances.

/pdf/efficient-long-distance-quantum-communication-2v3iqr2lwr.pdf

Sreraman Muralidharan

Papers

Optimal architectures for long distance quantum communication

Ultrafast and Fault-Tolerant Quantum Communication across Long Distances

Perfect Teleportation, Quantum state sharing and Superdense Coding through a Genuinely Entangled Five-qubit State

Quantum-information splitting using multipartite cluster states

Efficient long distance quantum communication