S
Sridhar K. Rabindran
Researcher at GlaxoSmithKline
Publications - 30
Citations - 4863
Sridhar K. Rabindran is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Kinase & Heat shock factor. The author has an hindex of 23, co-authored 30 publications receiving 4599 citations. Previous affiliations of Sridhar K. Rabindran include National Institutes of Health & American Cyanamid.
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Journal ArticleDOI
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
Kwak Eunice L,Raffaella Sordella,Daphne W. Bell,Godin-Heymann Nadia G,Ross A. Okimoto,Brian W. Brannigan,Patricia L. Harris,David R. Driscoll,Panos Fidias,Thomas J. Lynch,Sridhar K. Rabindran,John P. McGinnis,Allan Wissner,Sreenath V. Sharma,Kurt J. Isselbacher,Jeffrey Settleman,Daniel A. Haber +16 more
TL;DR: These findings suggest that one of these, HKI-272, may prove highly effective in the treatment of EGFR-mutant NSCLCs, including tumors that have become resistant to gefitinib or erlotinib.
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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
Jeffrey M. Axten,Jesus R. Medina,Yanhong Feng,Arthur Shu,Stuart Paul Romeril,Seth W. Grant,William Hoi Hong Li,Dirk A. Heerding,Elisabeth A. Minthorn,Thomas Mencken,Charity Atkins,Qi Liu,Sridhar K. Rabindran,Rakesh Kumar,Xuan Hong,Aaron S. Goetz,Thomas B. Stanley,J. David Taylor,Scott D Sigethy,Ginger H. Tomberlin,Annie M. Hassell,Kirsten M. Kahler,Lisa M. Shewchuk,Robert T. Gampe +23 more
TL;DR: Through screening and lead optimization using the human PERK crystal structure, compound 38 (GSK2606414), an orally available, potent, and selective PERK inhibitor is discovered, which inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice.
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Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
TL;DR: The results suggest that the carboxyl-terminal zipper may suppress formation of trimers by the amino- terminal HSF zipper elements by means of intramolecular coiled-coil interactions that are sensitive to heat shock.
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Displacement of sequence-specific transcription factors from mitotic chromatin
TL;DR: In vivo footprinting and immunocytochemical analyses revealed that all of the sequence-specific transcription factors were displaced from promoter sequences as well as from bulk chromatin during mitosis, suggesting an involvement of chromatin structure in mitotic repression.
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Molecular cloning and expression of a human heat shock factor, HSF1.
TL;DR: Surprisingly, an independently isolated human HSF clone, HSF2, is related to but significantly different from HSF1, suggesting that the intrinsic activity of HSF is under negative control in human cells.