Srinivas K. Kumar

TL;DR: In this paper, a series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines, and the results showed that the chalcone derivatives are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

TL;DR: An overview of sesquiterpenes, a class of naturally occurring molecules that have demonstrated therapeutic potential in decreasing the progression of cancer, are provided.

TL;DR: The lead compound 2 (RA-1) inhibits proteasomal activity and has improved dose-dependent antiproliferative and proapoptotic properties in cervical cancer cells containing human papillomavirus and induces synergistic killing of cervical cancer cell lines when tested in combination with an FDA approved proteasome inhibitor.

TL;DR: Modulating cyclopamine at the secondary amine with PSA-cleavable peptides is a promising strategy for developing prodrugs to target prostate cancer.

TL;DR: The EDA-derived prodrug of paclitaxel 5 was stable and capable of being efficiently converted to an active drug that killed cells specifically in the presence of PSA, suggesting that this prodrug and similarly designed PSA-cleavable prodrugs may have potential as prostate cancer-specific therapeutic agents.