J
John T. Isaacs
Researcher at Johns Hopkins University
Publications - 388
Citations - 29724
John T. Isaacs is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 88, co-authored 356 publications receiving 28217 citations. Previous affiliations of John T. Isaacs include Kanazawa Medical University & The Breast Cancer Research Foundation.
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Journal ArticleDOI
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.
Emmanuel S. Antonarakis,Changxue Lu,Hao Wang,Brandon Luber,Mary Nakazawa,Jeffrey C. Roeser,Yan Chen,Tabrez A. Mohammad,Yi Chen,Helen L. Fedor,Tamara L. Lotan,Qizhi Zheng,Angelo M. De Marzo,John T. Isaacs,William B. Isaacs,Rosa Nadal,Channing J. Paller,Samuel R. Denmeade,Michael A. Carducci,Mario A. Eisenberger,Jun Luo +20 more
TL;DR: In this article, the androgen-receptor splice variant 7 (AR-V7) was found to be associated with resistance to enzalutamide and abiraterone.
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KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.
Jin-Tang Dong,Patricia W. Lamb,Carrie W. Rinker-Schaeffer,Jasminka Vukanovic,Tomohiko Ichikawa,John T. Isaacs,J C Barrett +6 more
TL;DR: A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells.
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Activation of programmed cell death in the rat ventral prostate after castration.
Natasha Kyprianou,John T. Isaacs +1 more
TL;DR: Flow cytometric analysis of nuclear DNA content demonstrated that each day after castration, a subpopulation of androgen-dependent cells in rat ventral prostate fragmented all of their genomic DNA, as opposed to the whole population of cells fragmenting an increasing portion of their DNA daily.
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A history of prostate cancer treatment
TL;DR: The increased incidence of prostate cancer has led to remarkable changes in diagnosis and treatment over the past century, and how did these evolve into the variety of therapeutic strategies from which patients have to choose today?
Journal ArticleDOI
Etiology and disease process of benign prostatic hyperplasia
John T. Isaacs,Donald S. Coffey +1 more
TL;DR: The natural history of benign prostatic hyperplasia (BPH) involves two phases, termed microscopic and macroscopic BPH, neither of which produces symptomatic clinical dysuria, suggesting that additional factors are required for the progression of microscopic to macroscopy BPH.