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§ and Anne Schmitt-Hoffmann
Researcher at Hoffmann-La Roche
Publications - 1
Citations - 59
§ and Anne Schmitt-Hoffmann is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: DNA gyrase & Antibacterial activity. The author has an hindex of 1, co-authored 1 publications receiving 57 citations.
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New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine
Peter Angehrn,Stefan Buchmann,Christoph Funk,Erwin Goetschi,Hans Gmuender,Paul Hebeisen,Dirk Kostrewa,Helmut Link,Thomas Luebbers,Raffaello Masciadri,Joergen Nielsen,Peter Reindl,Fabienne Ricklin,§ and Anne Schmitt-Hoffmann,Frank-Peter Theil +14 more
TL;DR: Improving the pharmacokinetic properties of the most active compounds, in particular by lowering their lipophilic properties, was able to identify congeners of cyclothialidine that showed efficacy in vivo, and a modification program afforded a number of inhibitors that showed in vitro activity against Gram-positive bacteria.