E
Erwin Goetschi
Researcher at Hoffmann-La Roche
Publications - 54
Citations - 707
Erwin Goetschi is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Metabotropic glutamate receptor & Alkyl. The author has an hindex of 18, co-authored 54 publications receiving 678 citations.
Papers
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Journal ArticleDOI
New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine
Peter Angehrn,Stefan Buchmann,Christoph Funk,Erwin Goetschi,Hans Gmuender,Paul Hebeisen,Dirk Kostrewa,Helmut Link,Thomas Luebbers,Raffaello Masciadri,Joergen Nielsen,Peter Reindl,Fabienne Ricklin,§ and Anne Schmitt-Hoffmann,Frank-Peter Theil +14 more
TL;DR: Improving the pharmacokinetic properties of the most active compounds, in particular by lowering their lipophilic properties, was able to identify congeners of cyclothialidine that showed efficacy in vivo, and a modification program afforded a number of inhibitors that showed in vitro activity against Gram-positive bacteria.
Journal ArticleDOI
A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties.
Peter Angehrn,Erwin Goetschi,Hans Gmuender,Paul Hebeisen,Michael Hennig,Bernd Kuhn,Thomas Luebbers,Peter Reindl,Fabienne Ricklin,Anne Schmitt-Hoffmann +9 more
TL;DR: After adjusting their lipophilicity by methyl-halogen exchange at the benzene ring, compounds of this series did not require the thioamide functionality to exert a decent antibacterial potency and consequently exhibited improved pharmacokinetic properties resulting in a pronounced in vivo efficacy in a mouse septicaemia infection model.
Patent
Modulators for amyloid beta
TL;DR: In this article, the authors defined a class of compounds of formula (I) R1 is -C(O)O-lower alkyl, cyano or is hetaryl; R2 is hydrogen, lower alkoxy, lower alkyls, halogen or cyano.
Journal ArticleDOI
Cyclothialidine and its congeners: A new class of DNA gyrase inhibitors
Erwin Goetschi,Peter Angehrn,Hans Gmuender,Paul Hebeisen,Helmut Link,Raffaello Masciadri,Joergen Nielsen +6 more
TL;DR: The DNA gyrase inhibitory principle contained in cyclothialidine can be considered as the basis for a new class of antibacterial agents.
Journal ArticleDOI
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas Johannes Woltering,Juergen Wichmann,Erwin Goetschi,Frédéric Knoflach,Theresa M. Ballard,Joerg Huwyler,Silvia Gatti +6 more
TL;DR: Combination studies with a cholinesterase inhibitor show apparent synergistic effects on working memory impairment induced by scopolamine in the delayed match to position task.