S
Stacy M. Horner
Researcher at Duke University
Publications - 75
Citations - 4488
Stacy M. Horner is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Innate immune system. The author has an hindex of 29, co-authored 65 publications receiving 3405 citations. Previous affiliations of Stacy M. Horner include Durham University & University of Washington.
Papers
More filters
Journal ArticleDOI
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus
TL;DR: It is shown that a major site of MAVS signaling is the mitochondrial-associated membrane (MAM), a distinct membrane compartment that links the endoplasmic reticulum to mitochondria, which mediates an intracellular immune synapse that directs antiviral innate immunity.
Journal ArticleDOI
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.
Nathan M. Sherer,Maik J. Lehmann,Luisa F. Jimenez-Soto,Alyssa Ingmundson,Stacy M. Horner,Gregor Cicchetti,Philip G. Allen,Marc Pypaert,James M. Cunningham,Walther Mothes +9 more
TL;DR: It is demonstrated that HIV Gag and murine leukemia virus (MLV) Gag also drive assembly intracellularly in cell types including 293 and HeLa cells, previously believed to exclusively support budding from the plasma membrane.
Journal ArticleDOI
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
Nandan S. Gokhale,Alexa B. R. McIntyre,Michael J. McFadden,Allison E. Roder,Edward M. Kennedy,Jorge Gandara,Sharon E. Hopcraft,Kendra M. Quicke,Kendra M. Quicke,Christine Vazquez,Jason R. Willer,Olga Ilkayeva,Brittany A. Law,Christopher L. Holley,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Matthew J. Evans,Mehul S. Suthar,Mehul S. Suthar,Shelton S. Bradrick,Christopher E. Mason,Stacy M. Horner +21 more
TL;DR: It is demonstrated that m6A modulates infection by hepatitis C virus (HCV) and is identified as a conserved regulatory mark across Flaviviridae genomes.
Journal ArticleDOI
Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression.
Edward M. Kennedy,Hal P. Bogerd,Anand V.R. Kornepati,Dong Kang,Delta Ghoshal,Joy B. Marshall,Brigid Chiyoko Poling,Kevin Tsai,Nandan S. Gokhale,Stacy M. Horner,Bryan R. Cullen +10 more
TL;DR: photo-crosslinking-assisted m(6)A sequencing techniques are used to precisely map several m( 6)A editing sites on the HIV-1 genome and report that they cluster in the 3' untranslated region (3' UTR).
Journal ArticleDOI
Regulation of hepatic innate immunity by hepatitis C virus
Stacy M. Horner,Michael Gale +1 more
TL;DR: Recent insights into how HCV regulates innate immune signaling within the liver reveal a complex interaction of patient genetic background with viral and host factors of innate immune triggering and control that imparts the outcome of HCV infection and immunity.