S
Stacy S. Shord
Researcher at University of North Carolina at Chapel Hill
Publications - 12
Citations - 728
Stacy S. Shord is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Pharmacokinetics & Hydroxylation. The author has an hindex of 10, co-authored 12 publications receiving 700 citations.
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Journal Article
Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity
Stephanie R. Faucette,Roy L. Hawke,Edward L. LeCluyse,Stacy S. Shord,Bingfang Yan,Ronald M. Laethem,Celeste Lindley +6 more
TL;DR: Results demonstrate selectivity of BUP hydroxylation for CYP2B6 at 500 microM BUP, thereby validating its use as a diagnostic in vitro marker of CYP 2B6 catalytic activity.
Journal ArticleDOI
The Effect of Cyclophosphamide with and without Dexamethasone on Cytochrome P450 3A4 and 2B6 in Human Hepatocytes
Celeste Lindley,G. Hamilton,Jeannine S. McCune,Stephanie R. Faucette,Stacy S. Shord,Roy L. Hawke,Hongbing Wang,Darryl Gilbert,Summer Jolley,Bingfang Yan,Edward L. LeCluyse +10 more
TL;DR: Results indicate that CPA alone and in combination with DEX differentially induces the expression of CYP3A4 and 2B in a concentration-dependent manner, which may be mediated partially through activation of PXR.
Journal Article
Evaluation of the Contribution of Cytochrome P450 3A4 to Human Liver Microsomal Bupropion Hydroxylation
TL;DR: It is suggested that CYP3A4 does not significantly catalyze BUP hydroxylation, and this results complement recent data supporting selectivity of B UP hydroxymation for CYP2B6 at 500 microM BUP.
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Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes
Jasminder Sahi,Stacy S. Shord,Celeste Lindley,Stephen S. Ferguson,Edward L. LeCluyse,Edward L. LeCluyse +5 more
TL;DR: It is demonstrated that hepatic CYP2C9 is differentially regulated by agonists of CAR and PXR, and despite sharing common regulatory mechanisms with CYP3A4 and CYP 2B6; this enzyme exhibits an induction profile more closely aligned with that of CYP 3A4.
Journal ArticleDOI
Intraindividual variability in busulfan pharmacokinetics in patients undergoing a bone marrow transplant: assessment of a test dose and first dose strategy.
Celeste Lindley,Thomas B. Shea,Jeannine S. McCune,Stacy S. Shord,Jodi L. Decker,R. Donald Harvey,William P. Petros,Don Garbriel,Don Garbriel,Jonathan S. Serody,Suzanne L. Kirby,Suzanne L. Kirby,Joseph Wiley,Joseph Wiley +13 more
TL;DR: Monitoring busulfan concentrations after a test dose or a first dose provides a better estimate of the dose needed to achieve the target steady-state AUC as compared to traditional weight-based dosing, particularly if the desired target AUC range is narrow.