Showing papers by "Stanislav Groysman published in 2009"
TL;DR: This account describes the current status of the synthetic analogue approach as applied to the mononuclear Sites in certain molybdoenzymes and the polynuclear sites in hydrogenases, nitrogenase, and carbon monoxide dehydrogenases.
Abstract: Biomimetic inorganic chemistry has as its primary goal the synthesis of molecules that approach or achieve the structures, oxidation states, and electronic and reactivity features of native metal-containing sites of variant nuclearity. Comparison of properties of accurate analogues and these sites ideally provides insight into the influence of protein structure and environment on intrinsic properties as represented by the analogue. For polynuclear sites in particular, the goal provides a formidable challenge for, with the exception of iron-sulfur clusters, all such site structures have never been achieved and few have even been closely approximated by chemical synthesis. This account describes the current status of the synthetic analogue approach as applied to the mononuclear sites in certain molybdoenzymes and the polynuclear sites in hydrogenases, nitrogenase, and carbon monoxide dehydrogenases.
83 citations
TL;DR: A series of two-coordinate thiolate complexes was synthesized as possible reactants in forming analogues of the active site of Mo/Cu-containing carbon monoxide dehydrogenase and the structures of all complexes and 9 were determined.
Abstract: A series of two-coordinate thiolate complexes [Cu(SAr*)L] was synthesized as possible reactants in forming analogues of the active site of Mo/Cu-containing carbon monoxide dehydrogenase. Complexes ...
51 citations