Stanislav S. Kolesnikov

TL;DR: It is found that cyclic GMP acting from the inner side of the membrane markedly increases the cationic conductance of such patches of the rod outer segment in a reversible manner, while Ca2+ is ineffective.

TL;DR: The data indicate that tastant‐responsive taste cells release the neurotransmitter ATP via a non‐exocytotic mechanism dependent upon the generation of an action potential.

TL;DR: It is proposed that transducin, via phosphodiesterase, decreases cyclic nucleotide levels to activate the cyclic-nucleotide-suppressible conductance, leading to Ca2+ influx and taste-cell depolarization.

TL;DR: The data suggest that Panx1 alone forms a channel that has insufficient permeability to ATP, and perhaps, a distinct subunit and/or a regulatory circuit that is absent in taste cells is required to enable a high ATP-permeability mode of a native PanX1-based channel.

TL;DR: It is shown that ion channels responsible for voltage-gated outward currents in type II cells are ATP permeable and a strong correlation between the magnitude of the VG current and the intensity of ATP release is demonstrated, suggesting that slowly deactivating ion channels transporting the VG outward currents can also mediate ATP secretion intype II cells.