S
Stanley Shiigi
Publications - 5
Citations - 61
Stanley Shiigi is an academic researcher. The author has contributed to research in topics: Receptor & Toad. The author has an hindex of 5, co-authored 5 publications receiving 61 citations.
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Journal ArticleDOI
Apoptosis in thymus of adult Xenopus laevis
Laurens N. Ruben,Daniel R. Buchholz,Proochista Ahmadi,Rachel O. Johnson,Richard H. Clothier,Stanley Shiigi +5 more
TL;DR: The thymocytes of adult Xenopus laevis are susceptible to apoptosis when induced by a glucocorticoid, a lectin, and by altered self, antigen activation.
Journal ArticleDOI
The characterization of the toad splenocytes which bind mouse anti-human IL-2 receptor antibody.
TL;DR: The results clearly show that a phytohemagglutinin (PHA)/IL-2 sensitive splenocyte population is removed by NMU injection, and the predominant PHA activatable, r IL-2 binding cell populations of the toad appear to be T cells which are involved with helper and cytotoxic functions.
Journal ArticleDOI
Apoptosis in the thymus of developing Xenopus laevis
Laurens N. Ruben,Proochista Ahmadi,Rachel O. Johnson,Daniel R. Buchholz,Richard H. Clothier,Stanley Shiigi +5 more
TL;DR: Larval thymic apoptosis is glucocorticocoid- and thyroxine insensitive, but is lectin and altered-self antigen activated, particularly during postclimax stages.
Journal ArticleDOI
Toad splenocytes bind human IL-2 and anti-human IL-2 receptor antibody specifically
TL;DR: It appears that in spite of having some constitutive IL-2 receptors, a quantitative increase in receptor expression is required before immunological behavior can be effected.
Journal ArticleDOI
Impaired T cell functions during amphibian metamorphosis: IL-2 receptor expression and endogenous ligand production.
Laurens N. Ruben,Michelle A. Scheinman,Rachel O. Johnson,Stanley Shiigi,Richard H. Clothier,Michael Balls +5 more
TL;DR: It is demonstrated that human rIL-2 is not by itself mitogenic in the toad, but it can act as a co-stimulator of antigen-induced mitogenesis, and an absence of an endogenous ligand, coupled with a reduced capacity to express IL-2 receptors, may be responsible for impaired T cell clonal expansion in metamorphosing Xenopus.