L
Lorene K. Langeberg
Researcher at Oregon Health & Science University
Publications - 52
Citations - 9091
Lorene K. Langeberg is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Protein kinase A & A Kinase Anchor Proteins. The author has an hindex of 39, co-authored 52 publications receiving 8817 citations. Previous affiliations of Lorene K. Langeberg include Reed College & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Association of protein kinase A and protein phosphatase 2B with a common anchoring protein
Vincent M. Coghlan,Brian A. Perrino,Howard Monique L,Lorene K. Langeberg,James W. Hicks,Gallatin William M,John D. Scott +6 more
TL;DR: Results suggest that both PKA and CaN are targeted to subcellular sites by association with a common anchor protein and thereby regulate the phosphorylation state of key neuronal substrates.
Journal ArticleDOI
Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein
Theresa M. Klauck,Maree C. Faux,Kirstin Labudda,Lorene K. Langeberg,Susan Jaken,John D. Scott +5 more
TL;DR: Deletion analysis and binding studies demonstrate that a third enzyme, protein kinase C (PKC), binds AKAP79 at a site distinct from those bound by PKA or CaN, andAKAP79 appears to function as a scaffold protein for three multifunctional enzymes.
Journal ArticleDOI
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Marcie Colledge,Eric M. Snyder,Robert A. Crozier,Jacquelyn A. Soderling,Yetao Jin,Lorene K. Langeberg,Hua Lu,Mark F. Bear,John D. Scott +8 more
TL;DR: It is shown that PSD-95 is regulated by the ubiquitin-proteasome pathway, and data suggest that ubiquitination of PSd-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity.
Journal ArticleDOI
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Kimberly L. Dodge-Kafka,Kimberly L. Dodge-Kafka,Joseph Soughayer,Genevieve C. Pare,Jennifer J. Carlisle Michel,Lorene K. Langeberg,Michael S. Kapiloff,John D. Scott +7 more
TL;DR: Two coupled cAMP-dependent feedback loops are coordinated within the context of the mAKAP complex, suggesting that local control of cAMP signalling by AKAP proteins is more intricate than previously appreciated.
Journal ArticleDOI
Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex
Ryan S. Westphal,Steven J. Tavalin,Jerry W. Lin,Neal M. Alto,Iain D. C. Fraser,Lorene K. Langeberg,Morgan Sheng,John D. Scott +7 more
TL;DR: Yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity and targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation.