S
Stefania A. Nottola
Researcher at Sapienza University of Rome
Publications - 138
Citations - 3629
Stefania A. Nottola is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Oocyte & Zona pellucida. The author has an hindex of 34, co-authored 125 publications receiving 3221 citations. Previous affiliations of Stefania A. Nottola include American Board of Legal Medicine & University of Rome Tor Vergata.
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Journal ArticleDOI
Mitochondrial morphology in human fetal and adult female germ cells.
TL;DR: Oocyte mitochondria show dynamic morphological changes as they increase in number and populate different cell domains within the oocyte, according to the different energetic -metabolic needs of the cell during differentiation, maturation, and fertilization.
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Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin's disease.
Giuseppe Familiari,Alberto Caggiati,Stefania A. Nottola,Michele Ermini,Maria Rita Di Benedetto,Pietro M. Motta +5 more
TL;DR: The administration of contraceptive drugs before starting chemotherapy enhances survival of a greater number of ovarian follicles, as revealed by morphometric analyses, nevertheless, total ovarian protection is not assured and many undergo atresia, resulting in a shortened fertility period.
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Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles
Marie-Madeleine Dolmans,Nathalie Michaux,Alessandra Camboni,Belen Martinez-Madrid,Anne Van Langendonckt,Stefania A. Nottola,Jacques Donnez +6 more
TL;DR: Liberase treatment allows the isolation of highly viable follicles from human ovarian tissue, with an unaltered morphology and ultrastructure, and this purified endotoxin-free enzyme preparation is a promising alternative to impure collagenase preparations.
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Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle
Belen Martinez-Madrid,Alessandra Camboni,Alessandra Camboni,Marie-Madeleine Dolmans,Stefania A. Nottola,Anne Van Langendonckt,Jacques Donnez +6 more
TL;DR: Cryopreservation of intact human ovary with its vascular pedicle, according to the freeze-thawing protocol described here, is not associated with any signs of apoptosis or ultrastructural alterations in any cell types, and whole-organ vascular transplantation may be a viable option in the future.
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Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study.
Stefania A. Nottola,Alessandra Camboni,Alessandra Camboni,Anne Van Langendonckt,Dominique Demylle,Guido Macchiarelli,Marie-Madeleine Dolmans,Belen Martinez-Madrid,Silvia Correr,Jacques Donnez +9 more
TL;DR: Cryopreservation and xenotransplantation do not appear to greatly affect human primordial/primary follicle ultrastructure, and Interestingly, in frozen-thawed xenografts, secondary human ovarian follicles presented a well preserved ultrast structure, but asynchrony between oocyte and granulosa cell development was detected.